Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA.
Cell. 2015 Jun 18;161(7):1502-4. doi: 10.1016/j.cell.2015.06.005.
Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.
人类癌细胞具有复杂的染色体重排，这些重排可能是癌症发展的潜在驱动因素。然而，这些重排的分子机制尚不清楚。Zhang 等人使用一种结合活细胞成像和单细胞测序的新技术，证明了在随后的细胞周期中，错误分配到微核的染色体经常发生类似染色体碎裂的重排。
