局部应用硝酸锌复合溶液治疗100例肛门生殖器外部疣的疗效评估
Efficacy Assessment of a Topically Applied Nitric-Zinc Complex Solution for the Treatment of External Ano-genital Warts in 100 Patients.
作者信息
Ciccarese Giulia, Drago Francesco, Granger Corinne, Parodi Aurora
机构信息
University of Genoa, Genoa, Italy.
Dermatologic Clinic, San Martino Policlinic Hospital, Largo Rosanna Benzi, 10, 16132, Genoa, Italy.
出版信息
Dermatol Ther (Heidelb). 2019 Jun;9(2):327-335. doi: 10.1007/s13555-019-0300-7. Epub 2019 Apr 30.
INTRODUCTION
External ano-genital warts (AGWs) due to human papilloma virus infection are the most common sexually transmitted ano-genital lesions of viral origin worldwide. Treatments include topical chemicals/drugs, excisional surgery, cryosurgery, electrosurgery and laser surgery. Nitric-zinc complex (NZC) is a new topically applied solution containing nitric acid, zinc, copper and organic acids that induces a caustic effect on condyloma. The objective of this study was to investigate the efficacy and tolerability of NZC in the treatment of AGWs.
METHODS
Patients attending for AGWs between September 2016 and February 2018 were retrospectively studied. They received at least one NZC application for a maximum of four treatments (V0, V1, V2, V3) with average intervals of 25 days between sessions. Recurrences were evaluated at 3 and 6 months after clearance.
RESULTS
One hundred patients (70 males, 30 females) with a mean age of 36.39 years were studied. The total number of AGWs diagnosed at the baseline visit (V0) in all patients was 418 with a mean of 4.18 AGWs per patient. A wart cure rate of 92% was observed in ≤ 4 treatment sessions (383 lesions cured at visit 4, V4, out of 418 lesions at baseline), with a cure rate of 49% with only one NZC application. Complete clearance was observed in 25, 52, 72 and 84% of patients at V1, V2, V3 and V4, respectively. Relapses were observed in 29% of patients at 3 months and in 5% at 6 months. Of note, patients with ≤ 5 AGWs at V0 showed better clearance results than patients with > 5 lesions (p < 0.05). The treatment was well tolerated by most patients.
CONCLUSION
NZC has been demonstrated to be effective for AGWs after 1-4 treatment sessions, obtaining a good response from the first application. The better response in patients with fewer warts suggests that the earlier diagnosis is made and treatment started, the better the expected results.
FUNDING
ISDIN.
引言
由人乳头瘤病毒感染引起的外生殖器疣（AGWs）是全球最常见的病毒性性传播肛门生殖器病变。治疗方法包括局部使用化学药品/药物、切除手术、冷冻手术、电外科手术和激光手术。硝酸锌复合物（NZC）是一种新的局部应用溶液，含有硝酸、锌、铜和有机酸，对尖锐湿疣有腐蚀作用。本研究的目的是调查NZC治疗AGWs的疗效和耐受性。
方法
对2016年9月至2018年2月期间因AGWs就诊的患者进行回顾性研究。他们接受了至少一次NZC治疗，最多进行四次治疗（V0、V1、V2、V3），疗程之间的平均间隔为25天。在疣体清除后3个月和6个月评估复发情况。
结果
研究了100例患者（70例男性，30例女性），平均年龄36.39岁。所有患者在基线访视（V0）时诊断出的AGWs总数为418个，平均每位患者4.18个。在≤4个疗程的治疗中观察到疣体治愈率为92%（基线时418个疣体中，在第4次访视V4时治愈383个），仅应用一次NZC的治愈率为49%。在V1、V2、V3和V4时，分别有25%、52%、72%和84%的患者疣体完全清除。3个月时，29%的患者出现复发，6个月时为5%。值得注意的是，V0时AGWs≤5个的患者比疣体>5个的患者清除效果更好（p<0.05）。大多数患者对该治疗耐受性良好。
结论
已证明NZC在1-4个疗程的治疗后对AGWs有效，首次应用即可获得良好反应。疣体较少的患者反应更好，这表明诊断和治疗开始得越早，预期效果越好。
资金来源
ISDIN。
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