Matsubara M, Tango M, Nakagawa K
Horm Metab Res. 1987 Jan;19(1):31-4. doi: 10.1055/s-2007-1011729.
To try to determine the site and mode of action of dopamine (DA) on the secretion of gonadotropins in humans, 4 series of studies were performed in 19 healthy volunteers (7 healthy males, 5 females in follicular phase and 7 postmenopausal females). The intravenous infusion of DA at the rate of 4 micrograms/kg/min decreased plasma LH levels to 75.9 +/- 3.7 (mean +/- SE)% of the initial levels. The oral administration of 500 mg of levodopa (Dopa) also suppressed the concentration of plasma LH to 73.0 +/- 3.5%, but the pretreatment with two doses of 100 mg each of carbidopa (CD), a peripheral dopa decarboxylase inhibitor, attenuated this suppressing effect of Dopa on LH levels (nadir 82.4 +/- 4.1). Plasma FSH were not significantly altered by these drugs. On the other hand, the concentration of endogenous LRH in peripheral blood remained unchanged throughout the studies. The administration of CD alone had no effect on any of these 3 parameters. These results would suggest the direct suppressing effect of DA on pituitary gonadotrophs, although the modulation at the level of the hypothalamus also cannot be ruled out.
为了确定多巴胺（DA）对人类促性腺激素分泌的作用部位和作用方式，对19名健康志愿者（7名健康男性、5名处于卵泡期的女性和7名绝经后女性）进行了4组研究。以4微克/千克/分钟的速率静脉输注DA可使血浆促黄体生成素（LH）水平降至初始水平的75.9±3.7（平均值±标准误）%。口服500毫克左旋多巴（多巴）也可将血浆LH浓度抑制至73.0±3.5%，但预先给予两剂各100毫克的外周多巴脱羧酶抑制剂卡比多巴（CD）可减弱多巴对LH水平的这种抑制作用（最低点为82.4±4.1）。这些药物对血浆促卵泡生成素（FSH）无显著影响。另一方面，在整个研究过程中，外周血中内源性促性腺激素释放激素（LRH）的浓度保持不变。单独给予CD对这三个参数中的任何一个均无影响。这些结果表明DA对垂体促性腺细胞有直接抑制作用，尽管下丘脑水平的调节作用也不能排除。
