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左旋多巴和枸橼酸氯米芬对促黄体生成激素释放因子外周血浆水平的影响。

The effect of L-dopa and clomiphene citrate on peripheral plasma levels of luteinizing hormone-releasing factor.

作者信息

Polansky S, Muechler E, Sorrentino S

出版信息

Obstet Gynecol. 1976 Jul;48(1):79-83.

PMID:778710
Abstract

Response of luteinizing hormone-releasing factor (LRF) and gonadotropin levels to orally administered L-dopa and clomiphene citrate were measured in 13 healthy female volunteers. Testing was carried out during the early follicular phase of the menstrual cycle. The results indicated a suggestive but statistically nonsignificant elevation of peripheral plasma LRF following L-dopa administration but no response following clomiphene ingestion. No acute increase in gonadotropin levels was demonstrated in either group. A low but statistically significant positive correlation was found between luteinizing hormone and LRF values determined from the same samples.

摘要

在13名健康女性志愿者中,测量了促黄体生成激素释放因子(LRF)和促性腺激素水平对口服左旋多巴和枸橼酸氯米芬的反应。测试在月经周期的卵泡早期进行。结果表明,服用左旋多巴后外周血浆LRF有提示性升高,但无统计学意义,而服用枸橼酸氯米芬后无反应。两组均未显示促性腺激素水平有急性升高。在同一样本中测定的促黄体生成激素和LRF值之间发现了低但有统计学意义的正相关。

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