Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Rd East, Guelph, Ontario, N1G 2W1, Canada.
BMC Mol Cell Biol. 2019 Apr 11;20(1):8. doi: 10.1186/s12860-019-0191-6.
Dlx5 and Dlx6 stimulate differentiation of diverse progenitors during embryonic development. Their actions as pro-differentiation transcription factors includes the up-regulation of differentiation markers but the extent to which differentiation may also be stimulated by regulation of the cell cycle has not been addressed.
We document that expression of Dlx5 and Dlx6 antagonizes cell proliferation in a variety of cell types without inducing apoptosis or promoting cell cycle exit. Rather, a variety of evidence indicates that elevated Dlx5 and Dlx6 expression reduces the proportion of cells in S phase and affects the length of the cell cycle.
Antagonism of S-phase entry by Dlx5 and Dlx6 proteins likely represents a lineage-independent function to effect Dlx-mediated differentiation in multiple progenitor cell types.
Dlx5 和 Dlx6 在胚胎发育过程中刺激各种祖细胞的分化。它们作为促分化转录因子的作用包括上调分化标志物，但细胞周期的调节是否也能刺激分化尚未得到解决。
我们记录到 Dlx5 和 Dlx6 的表达在多种细胞类型中拮抗细胞增殖，而不诱导细胞凋亡或促进细胞周期退出。相反，各种证据表明，升高的 Dlx5 和 Dlx6 表达降低了 S 期细胞的比例，并影响了细胞周期的长度。
Dlx5 和 Dlx6 蛋白对 S 期进入的拮抗作用可能代表了一种谱系独立的功能，以影响多种祖细胞类型中的 Dlx 介导的分化。
