钯（II）催化 1-萘甲酰胺与α-氯代烷基酯的 C8-烷氧基羰基甲基化反应。
Pd(ii)-Catalyzed C8-H alkoxycarbonylmethylation of 1-naphthylamides with α-chloroalkyl esters.
机构信息
The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, PR China.
出版信息
Org Biomol Chem. 2019 May 15;17(19):4865-4868. doi: 10.1039/c9ob00648f.
An efficient protocol for palladium-catalyzed picolinamide directed C8-H alkoxycarbonylmethylation of 1-naphthylamine derivatives with α-chloroalkyl esters has been developed. The reaction exhibited a broad substrate scope and good functional group tolerance with high isolated yields. Note that α-chloroalkyl esters as a new type of alkylating reagent could be easily functionalized further due to their pending an ester group.
发展了一种高效的钯催化吡啶酰胺导向的 1-萘胺衍生物的 C8-H 烷氧基羰基甲基化反应，使用α-氯代烷基酯作为烷基化试剂。该反应具有广泛的底物范围和良好的官能团耐受性，收率高。需要注意的是，由于α-氯代烷基酯带有一个未反应的酯基，因此可以很容易地进一步进行功能化。
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