银（I）催化的 1-萘胺衍生物与偶氮二甲酸酯的 C4-H 胺化反应。
Silver(I)-Catalyzed C4-H Amination of 1-Naphthylamine Derivatives with Azodicarboxylates.
机构信息
The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, PR China.
Tetranov Biopharm, LLC. & Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou 450052, PR China.
出版信息
Org Lett. 2018 Feb 2;20(3):620-623. doi: 10.1021/acs.orglett.7b03749. Epub 2018 Jan 23.
A simple and efficient protocol for silver(I)-catalyzed picolinamide directed C4-H amination of 1-naphthylamine derivatives with readily available azodicarboxylates has been developed, demonstrating a new approach to 1,4-naphthalenediamine derivatives in high yields. Note that this reaction system could proceed under external-oxidant- and additive-free conditions (only requires 5 mol % of AgOAc as the catalyst in acetone).
已开发出一种简单高效的银（I）催化吡啶酰胺导向的 1-萘胺衍生物与易得的偶氮二羧酸酯的 C4-H 胺化反应协议，以高产率得到 1,4-萘二胺衍生物。值得注意的是，该反应体系可以在无外部氧化剂和添加剂的条件下进行（仅需在丙酮中使用 5 mol % 的 AgOAc 作为催化剂）。
Zotero 插件