The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, PR China.
Tetranov Biopharm, LLC. & Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou 450052, PR China.
Org Lett. 2018 Feb 2;20(3):620-623. doi: 10.1021/acs.orglett.7b03749. Epub 2018 Jan 23.
A simple and efficient protocol for silver(I)-catalyzed picolinamide directed C4-H amination of 1-naphthylamine derivatives with readily available azodicarboxylates has been developed, demonstrating a new approach to 1,4-naphthalenediamine derivatives in high yields. Note that this reaction system could proceed under external-oxidant- and additive-free conditions (only requires 5 mol % of AgOAc as the catalyst in acetone).
已开发出一种简单高效的银（I）催化吡啶酰胺导向的 1-萘胺衍生物与易得的偶氮二羧酸酯的 C4-H 胺化反应协议，以高产率得到 1,4-萘二胺衍生物。值得注意的是，该反应体系可以在无外部氧化剂和添加剂的条件下进行（仅需在丙酮中使用 5 mol % 的 AgOAc 作为催化剂）。
