1 Department of Laboratory, the Third People's Hospital of Linyi, Liyin, Shandong 276000, China.
2 Department of General Surgery, the Third People's Hospital of Linyi, Liyin, Shandong 276000, China.
Exp Biol Med (Maywood). 2019 Jun;244(9):734-742. doi: 10.1177/1535370219846492. Epub 2019 May 1.
The mechanism of gastric cancer is highly complex, accompanied by a variety of genetic abnormalities. It is of great significance to elucidate the pathogenesis of gastric cancer, find its markers and therapeutic targets in the fight against this fatal disease. In this study, we identified P2RX7 as a putative target of gastric cancer, which was overexpressed in gastric cancer tissues and had relationship with worse prognosis. We also elucidated the roles of P2RX7 on the growth and metastasis of gastric cancer cells, and explored the relationship between it and ERK1/2 pathway, Akt pathway, and epithelial-mesenchymal transition. Our findings begin to offer useful insights into the mechanism of gastric cancer progression and provide clues to novel therapy strategies.
胃癌的发病机制非常复杂，伴随着多种基因异常。阐明胃癌的发病机制，寻找其标志物和治疗靶点，对于抗击这种致命疾病具有重要意义。在这项研究中，我们鉴定了 P2RX7 是胃癌的一个潜在靶点，它在胃癌组织中过度表达，并与预后不良有关。我们还阐明了 P2RX7 对胃癌细胞生长和转移的作用，并探讨了它与 ERK1/2 通路、Akt 通路和上皮-间充质转化的关系。我们的研究结果开始为胃癌进展的机制提供了有用的见解，并为新的治疗策略提供了线索。
