Kaklamani E, Trichopoulos D, Papaevangelou G, Drouga M, Karalis D, Papoutsakis G
Infection. 1978;6(6):290-3. doi: 10.1007/BF01641989.
The incorporation of 14C-thymidine by peripheral blood lymphocytes stimulated by phytohemagglutinin (PHA) and the proportion and absolute number of E-rosettes were determined in 28 prostitutes and the results were correlated with hepatitis B virus (HBV) serology. Women were tested for hepatitis B surface antigen (HBsAg) and its antibody (anti-HBs) as well as for antibody to the hepatitis B core antigen (anti-HBc). It was found that women who were carriers of HBsAg had significantly lower incorporation of 14C-thymidine (median value 14451 counts per minute-cpm) compared to women positive for anti-HBc but negative for the other two markers (median value 28590 cpm) as well as to women negative for all the tested markers (median value 30600 cpm). No significant difference was found among the three groups studied with respect to either the absolute number or the percentage of E-rosettes. The results indicate that the presence of anti-HBc alone, is not related to the responsiveness of lymphocytes to PHA.
测定了28名妓女外周血淋巴细胞受植物血凝素（PHA）刺激后对14C-胸腺嘧啶核苷的掺入情况以及E玫瑰花结的比例和绝对数量，并将结果与乙型肝炎病毒（HBV）血清学进行关联。对这些女性进行了乙型肝炎表面抗原（HBsAg）及其抗体（抗-HBs）以及乙型肝炎核心抗原抗体（抗-HBc）检测。结果发现，与抗-HBc阳性但其他两项指标阴性的女性（中位数为每分钟28590计数-cpm）以及所有检测指标均为阴性的女性（中位数为每分钟30600计数-cpm）相比，HBsAg携带者的14C-胸腺嘧啶核苷掺入量显著更低（中位数为每分钟14451计数-cpm）。在所研究的三组中，E玫瑰花结的绝对数量或百分比均未发现显著差异。结果表明，单独存在抗-HBc与淋巴细胞对PHA的反应性无关。
