Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus, Denmark.
Department of Obstetrics and Gynaecology, Herlev and Gentofte Hospital, Herlev, Denmark.
Fertil Steril. 2019 Jul;112(1):120-129.e2. doi: 10.1016/j.fertnstert.2019.03.014. Epub 2019 Apr 28.
To investigate whether female coffee consumption affects the chance of achieving a clinical pregnancy and a live birth among women and couples receiving medically assisted reproduction (MAR) treatment.
Cohort study with prospectively collected exposure data.
Public fertility clinic.
PATIENT(S): A total of 1,708 women and potential partners undergoing fertility treatment, contributing with 1,511 intrauterine insemination (IUI) cycles, 2,870 in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, and 1,355 frozen embryo transfer cycles.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth in consecutive treatment cycles in the Danish national health registries, enabling complete follow-up, and estimation of the cumulative chance of live birth for three consecutive treatment cycles.
RESULT(S): Among women receiving IVF or ICSI treatment, coffee consumption did not seem to affect the chance of achieving a clinical pregnancy and a live birth. Women treated with IUI who had a daily coffee consumption of 1-5 cups were more likely to achieve a clinical pregnancy (adjusted relative risk 1.49; 95% confidence interval, 1.05-2.11) and live birth (adjusted relative risk 1.53; 95% confidence interval, 1.06-2.21) compared with the reference group of coffee abstainers.
CONCLUSION(S): Women consuming 1-5 cups versus none had a 1.5-fold higher probability of achieving a pregnancy or a live birth when receiving IUI. No associations were found, however, between women's daily coffee consumption and achieving a pregnancy or a live birth from IVF/ICSI.
探讨女性咖啡摄入量是否会影响接受医学辅助生殖（MAR）治疗的女性及其配偶妊娠临床妊娠和活产的几率。
前瞻性收集暴露数据的队列研究。
公立生育诊所。
共 1708 名接受生育治疗的女性及其潜在伴侣，贡献了 1511 个宫腔内人工授精（IUI）周期、2870 个体外受精（IVF）和卵胞浆内单精子注射（ICSI）周期以及 1355 个冷冻胚胎移植周期。
无。
丹麦国家健康登记处连续治疗周期的临床妊娠和活产，实现完全随访，并估计连续三个治疗周期的活产累积几率。
在接受 IVF 或 ICSI 治疗的女性中，咖啡摄入量似乎并未影响妊娠临床妊娠和活产的几率。每天饮用 1-5 杯咖啡的 IUI 治疗女性妊娠临床妊娠（调整后的相对风险 1.49；95%置信区间，1.05-2.11）和活产（调整后的相对风险 1.53；95%置信区间，1.06-2.21）的几率均高于不喝咖啡的参考组。
与不喝咖啡相比，IUI 治疗时每天饮用 1-5 杯咖啡的女性妊娠或活产的几率高 1.5 倍。然而，女性每日咖啡摄入量与 IVF/ICSI 的妊娠或活产几率之间未见关联。
