Huazhong University of Science and Technology, Tongji Medical College, Tongji Hospital, Reproductive Medicine Center, Wuhan, China.
Acta Obstet Gynecol Scand. 2022 Dec;101(12):1351-1363. doi: 10.1111/aogs.14464. Epub 2022 Oct 19.
The objective of this study was to evaluate the association between caffeine and alcohol consumption and in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes.
The protocol was registered in the PROSPERO database on May 23, 2021 (registration number: CRD42021256649), and updated on August 4, 2022. Two researchers performed a literature search in the PubMed, Embase, and MEDLINE databases for articles published before July 15, 2022 independently. Studies investigating the association between caffeine and alcohol consumption and IVF/ICSI outcomes were included, and studies reporting the consumption amount were analyzed using a one-stage robust error meta-regression-based method to explore potential dose-response relation. Funnel plot was used to assess publication bias if more than 10 studies were included.
Twelve studies on caffeine consumption and 14 studies on alcohol consumption were included in the systematic review, of which seven and nine were eligible for the meta-analysis. These studies included 26 922 women and/or their spouses who underwent IVF/ICSI treatment. Women's and men's caffeine consumption was not significantly associated with the pregnancy rate (odds ratio [OR] 0.97, 95% confidence interval [CI] 0.85-1.12; OR 0.93, 95% CI 0.75-1.14; respectively) and the live birth rate (OR 0.98, 95% CI 0.89-1.08; OR 0.98, 95% CI 0.86-1.12; respectively) of IVF/ICSI. Maternal alcohol consumption was negatively associated with pregnancy after IVF/ICSI treatment (OR 0.83, 95% CI 0.69-1.01). Paternal alcohol consumption was negatively associated with partner's live birth after IVF/ICSI treatment (OR 0.88, 95% CI 0.79-0.99). Compared with abstainers, the chance of achieving a pregnancy after IVF/ICSI treatment decreased by 7% for women who consumed 84 g alcohol per week (OR 0.93, 95% CI 0.90-0.98), and the chance of partners achieving a live birth decreased by 9% for men who consumed 84 g alcohol per week (OR 0.91, 95% CI 0.88-0.94).
There was no association between caffeine consumption and pregnancy or live birth rate of IVF/ICSI. Women's alcohol consumption was associated with decreased pregnancy rate after IVF/ICSI treatment when weekly consumption was greater than 84 g. Men's alcohol consumption was associated with decreased live birth rate after IVF/ICSI treatment when weekly consumption was greater than 84 g.
本研究旨在评估咖啡因和酒精摄入与体外受精（IVF）和卵胞浆内单精子注射（ICSI）结局之间的关联。
该方案于 2021 年 5 月 23 日在 PROSPERO 数据库中注册（注册号：CRD42021256649），并于 2022 年 8 月 4 日更新。两名研究人员于 2022 年 7 月 15 日之前在 PubMed、Embase 和 MEDLINE 数据库中独立进行了文献检索。纳入了研究咖啡因和酒精摄入与 IVF/ICSI 结局之间关联的研究，并使用基于一阶段稳健误差荟萃回归的方法分析了报告摄入量的研究，以探索潜在的剂量-反应关系。如果纳入的研究超过 10 项，则使用漏斗图评估发表偏倚。
系统评价共纳入了 12 项关于咖啡因摄入的研究和 14 项关于酒精摄入的研究，其中 7 项和 9 项符合荟萃分析的纳入标准。这些研究包括了 26922 名接受 IVF/ICSI 治疗的女性及其配偶。女性和男性的咖啡因摄入与 IVF/ICSI 的妊娠率（比值比[OR]0.97，95%置信区间[CI]0.85-1.12；OR 0.93，95%CI 0.75-1.14）和活产率（OR 0.98，95%CI 0.89-1.08；OR 0.98，95%CI 0.86-1.12）均无显著关联。母体酒精摄入与 IVF/ICSI 后妊娠率呈负相关（OR 0.83，95%CI 0.69-1.01）。父体酒精摄入与 IVF/ICSI 后伴侣的活产率呈负相关（OR 0.88，95%CI 0.79-0.99）。与不饮酒者相比，每周摄入 84g 酒精的女性 IVF/ICSI 后妊娠的几率降低了 7%（OR 0.93，95%CI 0.90-0.98），每周摄入 84g 酒精的男性 IVF/ICSI 后伴侣活产的几率降低了 9%（OR 0.91，95%CI 0.88-0.94）。
咖啡因摄入与 IVF/ICSI 的妊娠或活产率之间无关联。当每周饮酒量大于 84g 时，女性饮酒与 IVF/ICSI 后妊娠率降低有关。当每周饮酒量大于 84g 时，男性饮酒与 IVF/ICSI 后活产率降低有关。
