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电风暴——预后仍然极差。这些危及生命的心律失常的急性状态从一开始就需要多方面的治疗方法吗?

Electrical storm - still an extremely poor prognosis. Do these acute states of life-threatening arrhythmias require a multidirectional approach from the start?

作者信息

Gadula-Gacek Elżbieta, Tajstra Mateusz, Gąsior Mariusz

机构信息

3 Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Disease in Zabrze, Poland.

出版信息

Postepy Kardiol Interwencyjnej. 2019;15(1):1-12. doi: 10.5114/aic.2019.83769. Epub 2019 Apr 4.

DOI:10.5114/aic.2019.83769
PMID:31043979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6488832/
Abstract

Electrical storm (ES) is a state of electrical instability of the heart manifesting as multiple and potentially lethal recurring ventricular arrhythmias such as ventricular tachycardia or ventricular fibrillation. This definition is not related to the condition of each patient, who can present from asymptomatic to unconscious and in deep cardiogenic shock. Most patients affected by ES have heart failure (HF) of ischaemic origin. Ischaemia, exacerbation of HF, low ejection fraction, previous ventricular arrhythmias, infection or electrolyte disturbances together with other factors, or a few factors combined, may result in ES. The prognosis of ES survivors is very poor, with 1-year mortality exceeding 40%, which should draw attention to this group of patients as one of extremely high risk. The number of patients with cardioverter-defibrillators is increasing and so is the number of patients suffering from ES. Therefore, each patient should be supported with tailored therapy, and not only restricted to pharmacotherapy or ablation procedures. This paper was written to analyse the most frequent causes of ES and prompt the most appropriate clinical pathways and possibilities, underlining the need for a comprehensive invasive approach to diagnosis, treatment and circulatory stabilization in addition to adequate pharmacotherapy. This approach might help to reduce the mortality rate in this group of patients and improve the prognosis.

摘要

电风暴(ES)是一种心脏电不稳定状态,表现为多次反复发作且可能致命的室性心律失常,如室性心动过速或心室颤动。这一定义与每位患者的病情无关,患者可能无症状,也可能处于昏迷状态并伴有严重的心源性休克。大多数受ES影响的患者患有缺血性心力衰竭(HF)。缺血、HF加重、射血分数降低、既往室性心律失常、感染或电解质紊乱以及其他因素,或几种因素共同作用,都可能导致ES。ES幸存者的预后非常差,1年死亡率超过40%,这应引起对这一极高风险患者群体的关注。植入心脏复律除颤器的患者数量在增加,患ES的患者数量也在增加。因此,每位患者都应接受量身定制的治疗,而不仅限于药物治疗或消融手术。本文旨在分析ES最常见的病因,并提出最合适的临床路径和可能性,强调除了适当的药物治疗外,还需要采用全面的侵入性方法进行诊断、治疗和循环稳定。这种方法可能有助于降低该组患者的死亡率并改善预后。

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