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靶向claudin-3可抑制非鳞状非小细胞肺癌中的干细胞样表型。

Targeting claudin-3 suppresses stem cell-like phenotype in nonsquamous non-small-cell lung carcinoma.

作者信息

Ma Lin, Yin Wu, Ma Heliang, Elshoura Ihab, Wang Lan

机构信息

School of Materials Science & Engineering, South China University of Technology, Guangzhou 510640, China.

R&D Center, Guangzhou Ribobio Co., Ltd, Guangzhou 510663, China.

出版信息

Lung Cancer Manag. 2019 Feb 26;8(1):LMT04. doi: 10.2217/lmt-2018-0010. eCollection 2019 Feb.

DOI:10.2217/lmt-2018-0010
PMID:31044015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6488947/
Abstract

AIM

To determine the role of claudin-3 in cancer stemness in nonsquamous non-small-cell lung carcinoma (NSCLC).

MATERIALS & METHODS: extreme limiting dilution analysis and the side population assay were used to investigate the role of claudin-3 in regulating cancer stemness in nonsquamous NSCLC.

RESULTS & CONCLUSION: Claudin-3 depletion decreased the formation rates of spheres and tumors and increased cisplatin sensitivity. Claudin-3 was also identified as one downstream target of estrogen receptor-α in regulating cancer stemness. Moreover, targeting transcription by small molecules including withaferin A, estradiol and fulvestrant suppressed cancer stemness and reversed chemoresistance. These results demonstrated claudin-3 is one positive regulator of cancer stemness in nonsuqamous NSCLC.

摘要

目的

确定claudin-3在非鳞状非小细胞肺癌（NSCLC）的癌症干性中的作用。

材料与方法

采用极限稀释分析和侧群细胞分析来研究claudin-3在调节非鳞状NSCLC癌症干性中的作用。

结果与结论

claudin-3缺失降低了球体和肿瘤的形成率，并增加了顺铂敏感性。claudin-3也被确定为雌激素受体-α在调节癌症干性中的一个下游靶点。此外，用包括白藜芦醇A、雌二醇和氟维司群在内的小分子靶向转录可抑制癌症干性并逆转化疗耐药性。这些结果表明claudin-3是非鳞状NSCLC中癌症干性的一个正调节因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/aedd7c9dbcf1/lmt-08-04-g6a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/9cb7897f5d01/lmt-08-04-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/d29cd13f9a71/lmt-08-04-g2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/ec173db4a83f/lmt-08-04-g3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/3a84599bfd75/lmt-08-04-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/9e90779ff863/lmt-08-04-g5a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/aedd7c9dbcf1/lmt-08-04-g6a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/9cb7897f5d01/lmt-08-04-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/d29cd13f9a71/lmt-08-04-g2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/ec173db4a83f/lmt-08-04-g3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/3a84599bfd75/lmt-08-04-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/9e90779ff863/lmt-08-04-g5a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3372/6488947/aedd7c9dbcf1/lmt-08-04-g6a.jpg

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