Nuffield Department of Medicine, University of Oxford.
Eva Zilber and Genevieve E. Martin contributed equally to the article.
AIDS. 2019 Jun 1;33(7):1253-1256. doi: 10.1097/QAD.0000000000002165.
: Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.
可溶性共抑制受体程序性死亡 1（PD-1）和 Tim-3 存在，但它们与 T 细胞表面表达的关系尚不清楚。通过酶联免疫吸附试验在血浆中测量时，可溶性 PD-1 和可溶性 Tim-3 在原发性 HIV 感染期间升高，在抗逆转录病毒治疗后下降至对照组水平，并与细胞表面表达相关。我们得出结论，可溶性 PD-1 和可溶性 Tim-3 是易于测量的免疫耗竭生物标志物，这可能消除了对流式细胞术的需求。
