L-半胱氨酸对二碘羟基喹啉诱导的瑞士小鼠微核的生物抗诱变作用。
Bio-antimutagenic effect of L-cysteine on diiodohydroxyquinoline-induced micronuclei in Swiss mice.
作者信息
Ghaskadbi S, Pavaskar S V, Vaidya V G
出版信息
Mutat Res. 1987 Apr;187(4):219-22. doi: 10.1016/0165-1218(87)90039-5.
PMID:3104778
Abstract
The mutagenic potential of diiodohydroxyquinoline (DIHQ), a common anti-amebic drug, was tested using the in vivo micronucleus test in Swiss mice following oral administration. It was found to be mutagenic in a dose-dependent manner. Using the same model system, the bio-antimutagenic effect of the sulfhydryl compound L-cysteine against DIHQ was established.
摘要
使用体内微核试验，对常用抗阿米巴药物二碘羟基喹啉（DIHQ）在口服给药后对瑞士小鼠的诱变潜力进行了测试。结果发现它具有剂量依赖性诱变作用。利用相同的模型系统，确定了巯基化合物L-半胱氨酸对DIHQ的生物抗诱变作用。
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