Richardson J C, Richold M
Mutat Res. 1982 Dec;102(4):357-60. doi: 10.1016/0165-1218(82)90098-2.
The micronucleus test in mice was used to investigate the mutagenic potential of 2-(2',4'-diaminophenoxy)ethanol. The test compound was administered by oral gavage to CD-1 mice (ICR derived) as 2 equal dosages of 250,500 and 1000 mg/kg bodyweight. Bone-marrow smears were examined for the presence of micronucleated cells in 2000 polychromatic erythrocytes per animal. In addition, the ratio of normochromatic to polychromatic erythrocytes was scored to provide an indication of the toxicity of the test compound to bone marrow cells. No increase in the incidence of micronucleated polychromatic erythrocytes was observed for any group dosed with 2-(2',4'-diaminophenoxy)ethanol, although evidence of bone-marrow toxicity was observed at all 3 dosages.
采用小鼠微核试验来研究2-(2',4'-二氨基苯氧基)乙醇的诱变潜力。将受试化合物以250、500和1000mg/kg体重的2个等量剂量通过口服灌胃给予CD-1小鼠（源自ICR）。检查每只动物2000个多染性红细胞中的微核细胞情况。此外，对正染性红细胞与多染性红细胞的比例进行评分，以表明受试化合物对骨髓细胞的毒性。给予2-(2',4'-二氨基苯氧基)乙醇的任何组均未观察到多染性红细胞微核发生率增加，不过在所有3个剂量下均观察到了骨髓毒性迹象。
