Matsumura K, Nakayama T, Kaminaga T
Pflugers Arch. 1987 Feb;408(2):120-3. doi: 10.1007/BF00581339.
Effects of carbon dioxide (CO2) on the firing rates of preoptic thermosensitive neurons were examined in rat brain slice preparations. The perfusing medium was saturated with gas mixtures consisting of 90% O2 and one of various concentrations (5%, 6.3%, 7.5%, and 10%) of CO2 balanced with N2. The medium containing 5% CO2 was used as control. Most preoptic neurons were inhibited during application of a high CO2 medium. An excitatory effect of CO2 on a small number of neurons was also significant, although this was weak and transient compared to the inhibitory effect. Thermosensitivities of the neurons did not correlate with their CO2 sensitivities. The influence of CO2 tended to be more evident at higher temperatures. We conclude that the direct effect of CO2 on PO thermosensitive neurons as well as on thermally insensitive neurons is mainly inhibitory.
在大鼠脑片制备物中检测了二氧化碳（CO₂）对视前区热敏神经元放电频率的影响。灌注培养基用由90% O₂和各种浓度（5%、6.3%、7.5%和10%）的CO₂与N₂平衡组成的气体混合物饱和。含5% CO₂的培养基用作对照。在应用高CO₂培养基期间，大多数视前区神经元受到抑制。尽管与抑制作用相比，CO₂对少数神经元的兴奋作用较弱且短暂，但也很显著。神经元的热敏性与其CO₂敏感性无关。在较高温度下，CO₂的影响往往更明显。我们得出结论，CO₂对视前区热敏神经元以及对热不敏感神经元的直接作用主要是抑制性的。
