新生儿同种免疫性中性粒细胞减少症
Neonatal Alloimmune Neutropenia.
作者信息
Porcelijn Leendert, de Haas Masja
机构信息
Immunohematology Diagnostic Services, Sanquin Diagnostic Services, Amsterdam, the Netherlands.
Department of Immuno-Hematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Transfus Med Hemother. 2018 Oct;45(5):311-316. doi: 10.1159/000492949. Epub 2018 Sep 24.
Abstract
Neonatal alloimmune neutropenia (NAIN, NAIN or NIN) is a neutrophil blood group antagonism, analogous to hemolytic disease of the fetus and newborn (HDFN) and fetal/neonatal alloimmune thrombocytopenia (FNAIT). A limited number of prospective screening studies showed that granulocyte-specific antibodies were detectable in 0.35-1.1% of random postnatal maternal samples and that the incidence of NAIN was below 0.1%. Symptoms vary from none to mild skin infections, omphalitis or more severe infections like pneumonia, sepsis, and meningitis. Treatment of neonatal infection with antibiotics and granulocyte-colony stimulating factor is advised.
摘要
新生儿同种免疫性中性粒细胞减少症（NAIN、NAIN或NIN）是一种中性粒细胞血型拮抗，类似于胎儿和新生儿溶血病（HDFN）以及胎儿/新生儿同种免疫性血小板减少症（FNAIT）。少数前瞻性筛查研究表明，在随机抽取的产后母体样本中，0.35%-1.1%可检测到粒细胞特异性抗体，且NAIN的发病率低于0.1%。症状从无到轻度皮肤感染、脐炎或更严重的感染如肺炎、败血症和脑膜炎不等。建议用抗生素和粒细胞集落刺激因子治疗新生儿感染。
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