Department of Pediatric Hematology/Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
Pediatr Blood Cancer. 2010 Jul 1;54(7):1014-6. doi: 10.1002/pbc.22315.
Neonatal alloimmune neutropenia (NAIN) is a rare cause of congenital neutropenia seen in <1% of births. Significant morbidity, usually infections, may result from this disease. The pathophysiology of NAIN, mediated by maternal antibodies crossing the placenta to destroy fetal cells expressing paternal antigens, is similar to that of neonatal alloimmune thrombocytopenia, as well as Rh/ABO hemolytic disease of the newborn. The use of high-dose granulocyte colony stimulating factor in patients with NAIN may cause a reversible thrombocytopenia in some patients.
新生儿同种免疫性中性粒细胞减少症（NAIN）是一种罕见的先天性中性粒细胞减少症，在不到 1%的出生中可见。这种疾病可能导致严重的发病率，通常是感染。NAIN 的病理生理学是由母体抗体穿过胎盘破坏表达父系抗原的胎儿细胞介导的，与新生儿同种免疫性血小板减少症以及 Rh/ABO 新生儿溶血病相似。在 NAIN 患者中使用高剂量粒细胞集落刺激因子可能会导致一些患者出现可逆性血小板减少症。
