Department of Nephrology, Jagiellonian University Medical College, 15C Kopernika Street, 31-501, Cracow, Poland.
Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623, Hannover, Germany.
Amino Acids. 2019 Jun;51(6):977-982. doi: 10.1007/s00726-019-02738-x. Epub 2019 May 2.
High plasma osteoprotegerin (OPG) and asymmetric dimethylarginine (ADMA) and low homoarginine (hArg) predict adverse renal and cardiovascular (CV) outcomes. In patients with chronic kidney disease and stable coronary artery disease, plasma OPG correlated with hArg (r = - 0.37, P = 0.03) and the hArg/ADMA molar ratio (r = - 0.46, P = 0.009), which was maintained upon adjustment for renal function. Elevated OPG levels and decreased hArg/ADMA ratios independently predicted 4-year composite CV and renal endpoints (CV death or progression to dialysis). Thus, high OPG and low hArg/ADMA ratio, albeit interrelated, appear to independently contribute to adverse clinical outcome.
高血浆护骨素（OPG）和不对称二甲基精氨酸（ADMA）以及低同型精氨酸（hArg）预示不良的肾脏和心血管（CV）结局。在患有慢性肾脏病和稳定型冠状动脉疾病的患者中，血浆 OPG 与 hArg（r=-0.37，P=0.03）和 hArg/ADMA 摩尔比（r=-0.46，P=0.009）相关，在调整肾功能后仍保持相关性。升高的 OPG 水平和降低的 hArg/ADMA 比值独立预测了 4 年复合 CV 和肾脏终点（CV 死亡或进展至透析）。因此，尽管相互关联，高 OPG 和低 hArg/ADMA 比值似乎独立地导致不良临床结局。
