抗癫痫药物在汗液中的排泄。

Excretion of antiepileptic drugs in sweat.

作者信息

Parnas J, Flachs H, Gram L, Würtz-Jørgensen A

出版信息

Acta Neurol Scand. 1978 Sep;58(3):197-204. doi: 10.1111/j.1600-0404.1978.tb02879.x.

DOI:10.1111/j.1600-0404.1978.tb02879.x

Abstract

In eight epileptic patients receiving chronic antiepileptic treatment, a study of the excretion in sweat of phenytoin, phenobarbitone and carbamazepine was performed. All three drugs were found to be present in sweat. Phenytoin sweat concentration was found to correspond to the free fraction in plasma and to be independent of sweat flow. Phenobarbitone sweat concentration was found to increase with increasing sweat flow. Regarding drug level monitoring it is proposed that under changing climatic conditions the phenomenon may be of clinical significance.

摘要

在八名接受慢性抗癫痫治疗的癫痫患者中，对苯妥英、苯巴比妥和卡马西平在汗液中的排泄情况进行了研究。发现所有这三种药物都存在于汗液中。发现苯妥英的汗液浓度与血浆中的游离部分相对应，且与汗液流量无关。发现苯巴比妥的汗液浓度随着汗液流量的增加而升高。关于药物水平监测，有人提出在气候条件变化时，这种现象可能具有临床意义。