Department of Radiology, Guizhou Provincial People's Hospital, Guiyang, China; Department of Radiology, Michigan State University, East Lansing, MI, USA.
Department of Medicine, Michigan State University, East Lansing, MI, USA.
J Magn Reson. 2019 Jun;303:121-127. doi: 10.1016/j.jmr.2019.04.014. Epub 2019 Apr 25.
To map the hemodynamic responses of kidney microstructures at 7.05 T with improved sensitivity, a Wireless Amplified NMR Detector (WAND) with cylindrical symmetry was fabricated as an endoluminal detector that can convert externally provided wireless signal at 600.71 MHz into amplified MR signals at 300.33 MHz. When this detector was inserted inside colonic lumens to sensitively observe adjacent kidneys, it could clearly identify kidney microstructures in the renal cortex and renal medullary. Owing to the higher achievable spatial resolution, differential hemodynamic responses of kidney microstructures under different breathing conditions could be individually quantified to estimate the underlying correlation between oxygen bearing capability and local levels of oxygen unsaturation. The WAND's ability to map Blood Oxygen Level Dependent (BOLD) signal responses in heterogeneous microstructures will pave way for early-stage diagnosis of kidney diseases, without the use of contrast agents for reduced tissue retention and toxicity.
为了以更高的灵敏度绘制出 7.05T 下肾脏微结构的血液动力学响应，我们设计了一种具有圆柱对称性的无线放大 NMR 探测器（WAND）作为内腔式探测器，它可以将外部提供的 600.71MHz 的无线信号转换为 300.33MHz 的放大 MR 信号。当该探测器插入结肠腔内部以灵敏地观察相邻的肾脏时，它可以清楚地识别肾皮质和肾髓质中的肾脏微结构。由于可实现更高的空间分辨率，因此可以单独量化不同呼吸条件下肾脏微结构的差异血液动力学响应，以估计携氧能力与局部氧不饱和水平之间的潜在相关性。WAND 能够绘制不均匀微结构中的血氧水平依赖（BOLD）信号响应，这将为早期诊断肾脏疾病铺平道路，无需使用对比剂来减少组织保留和毒性。
