Duret J L
Acta Anaesthesiol Belg. 1986;37(4):237-41.
The use of alfentanil was studied in 49 patients undergoing surgery with a duration of at least 90 minutes. Induction was performed with droperidol (Dehydrobenzperidol) and etomidate (Hypnomidate), maintenance with nitrous oxide/oxygen 2:1 and alfentanil. Alfentanil was administered as an initial bolus of 2-3 mg depending on the body weight of the patient, immediately followed by a continuous infusion of 0.75 microgram/kg/min. In case a stressful or painful event in surgery caused inadequate analgesia, additional increments of 1 mg of alfentanil were administered. Anesthesia was considered to be good in 90% of the patients. The number of additional increments needed did not increase as the anesthetic procedure progressed in time. In virtually all patients postoperative recovery was fast and not related to the number of increments. It is concluded that alfentanil infusion for longer procedures in combination with nitrous oxide/oxygen provided a good and easy method for maintaining a satisfactory level of analgesia.
对49例手术时间至少90分钟的患者使用阿芬太尼进行了研究。诱导麻醉采用氟哌利多（氟哌啶醇）和依托咪酯（甲苄咪唑），维持麻醉采用氧化亚氮/氧气（2:1）和阿芬太尼。根据患者体重，阿芬太尼初始推注剂量为2 - 3毫克，随后立即以0.75微克/千克/分钟的速度持续输注。如果手术中出现应激或疼痛事件导致镇痛不足，则额外追加1毫克阿芬太尼。90%的患者麻醉效果良好。随着麻醉过程的推进，所需额外追加剂量的次数并未增加。几乎所有患者术后恢复迅速，且与追加剂量次数无关。结论是，在较长手术过程中，阿芬太尼输注联合氧化亚氮/氧气为维持满意的镇痛水平提供了一种良好且简便的方法。
