Steegers P A, Booij L H, Pelgrom R
Acta Anaesthesiol Belg. 1982;33(2):81-7.
The administration of alfentanil by continuous infusion as supplementation to nitrous oxide for shortlasting anesthesias has been studied in 51 patients. Anesthesia was induced with thiopental 4 to 5 mg/kg-1. Analgesia was performed by a continuous infusion of alfentanil (0.1 mg.ml-1 in glucose 5%) preceded by a bolus injection of 0.5 mg alfentanil i.v. Supplementations of 0.25 mg alfentanil i.v. were given if indicated. The patients were divided into 4 groups, according to the rate of infusion (group I: 4 mg.hr-1; group II: 5 mg.hr-1) and to the addition of either droperidol (group III) or domperidone (group IV). Anesthesia was satisfactory in all cases. Alfentanil given by continuous infusion (4 mg/hr-1) preceded by a bolus injection (0.5 mg) provided a good basic analgesia. With this method of administration the awakening time was shorter and less analgesic was needed than after incremental dosages of alfentanil. Droperidol, almost abolished nausea and vomiting postoperatively. It, however, clearly potentiated the effect of alfentanil. Domperidone given instead of droperidol had no or little effect on postoperative nausea and vomiting.
对51例患者进行了研究，采用持续输注阿芬太尼作为补充，与氧化亚氮联合用于短暂麻醉。用硫喷妥钠4～5mg/kg-1诱导麻醉。镇痛通过持续输注阿芬太尼（5%葡萄糖溶液中0.1mg/ml）进行，先静脉推注0.5mg阿芬太尼。必要时静脉追加0.25mg阿芬太尼。根据输注速率（I组：4mg/hr-1；II组：5mg/hr-1）以及是否加用氟哌利多（III组）或多潘立酮（IV组）将患者分为4组。所有病例麻醉效果均满意。持续输注阿芬太尼（4mg/hr-1）并先静脉推注（0.5mg）可提供良好的基础镇痛。采用这种给药方法，苏醒时间较短，且与递增剂量阿芬太尼给药后相比所需镇痛药更少。氟哌利多几乎消除了术后恶心和呕吐。然而，它明显增强了阿芬太尼的作用。用多潘立酮替代氟哌利多对术后恶心和呕吐无影响或影响很小。
