Ong Samantha Kah Ling, Shanmugam Muthu K, Fan Lu, Fraser Sarah E, Arfuso Frank, Ahn Kwang Seok, Sethi Gautam, Bishayee Anupam
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.
Cancers (Basel). 2019 May 1;11(5):611. doi: 10.3390/cancers11050611.
Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including the red clover ( and Chinese medicinal plant Formononetin's antioxidant and neuroprotective effects underscore its therapeutic use against Alzheimer's disease. Formononetin has been under intense investigation for the past decade as strong evidence on promoting apoptosis and against proliferation suggests for its use as an anticancer agent against diverse cancers. These anticancer properties are observed in multiple cancer cell models, including breast, colorectal, and prostate cancer. Formononetin also attenuates metastasis and tumor growth in various in vivo studies. The beneficial effects exuded by formononetin can be attributed to its antiproliferative and cell cycle arrest inducing properties. Formononetin regulates various transcription factors and growth-factor-mediated oncogenic pathways, consequently alleviating the possible causes of chronic inflammation that are linked to cancer survival of neoplastic cells and their resistance against chemotherapy. As such, this review summarizes and critically analyzes current evidence on the potential of formononetin for therapy of various malignancies with special emphasis on molecular targets.
芒柄花黄素是一种异黄酮，可从包括红三叶草在内的多种药用植物和草药中提取（以及中国药用植物 芒柄花黄素的抗氧化和神经保护作用突出了其对阿尔茨海默病的治疗用途。在过去十年中，芒柄花黄素一直受到深入研究，因为有强有力的证据表明其具有促进细胞凋亡和抗增殖作用，这表明它可作为一种抗癌剂用于治疗多种癌症。在包括乳腺癌、结直肠癌和前列腺癌在内的多种癌细胞模型中都观察到了这些抗癌特性。在各种体内研究中，芒柄花黄素还能减轻转移和肿瘤生长。芒柄花黄素所展现出的有益效果可归因于其抗增殖和诱导细胞周期停滞的特性。芒柄花黄素调节各种转录因子和生长因子介导的致癌途径，从而减轻与肿瘤细胞的癌症存活及其对化疗的抗性相关的慢性炎症的可能成因。因此，本综述总结并批判性地分析了目前关于芒柄花黄素治疗各种恶性肿瘤潜力的证据，特别强调了分子靶点。 ）
需注意，原文中“and Chinese medicinal plant Formononetin's antioxidant”表述似乎不太准确完整，译文括号内为尽量完善语句逻辑后的内容。
