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米糠灰分矿物提取物通过 p-ERK 通路增加斑马鱼的色素沉着 ()。

Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish ().

机构信息

Department of Medical Biotechnology (BK21 Plus Team), Dongguk University, Goyang-si 10326, Korea.

出版信息

Int J Mol Sci. 2019 May 2;20(9):2172. doi: 10.3390/ijms20092172.

DOI:10.3390/ijms20092172
PMID:31052497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6539449/
Abstract

The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish.

摘要

本研究旨在评估米糠灰矿物提取物（RBM）对斑马鱼色素沉着的影响。黑色素具有阻挡紫外线（UV）辐射和清除自由基的能力，从而保护皮肤免受其有害影响。增加黑素细胞中黑色素合成的物质可能会降低光损伤和皮肤癌的风险。本研究调查了 RBM 对斑马鱼色素沉着的影响及其潜在机制。研究发现，RBM 显著增加了小眼畸形相关转录因子（MITF）的表达，MITF 是参与黑色素生成的关键转录因子。RBM 还抑制了细胞外信号调节激酶（ERK）的磷酸化，ERK 负调控斑马鱼的色素沉着。综上所述，这些结果表明 RBM 促进了斑马鱼黑色素的生物合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/8880ebf8c162/ijms-20-02172-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/25c5e3ae6ddc/ijms-20-02172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/3eaf0d19872b/ijms-20-02172-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/7aa7c0809280/ijms-20-02172-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/8880ebf8c162/ijms-20-02172-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/25c5e3ae6ddc/ijms-20-02172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/3eaf0d19872b/ijms-20-02172-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/7aa7c0809280/ijms-20-02172-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa4/6539449/8880ebf8c162/ijms-20-02172-g004.jpg

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