Grimmond T R, Brownridge P
Anaesth Intensive Care. 1986 Nov;14(4):418-20. doi: 10.1177/0310057X8601400415.
The antimicrobial activity of bupivacaine and pethidine in concentrations commonly used in epidural practice was studied by an agar dilution method against ten common micro-organisms. Both drugs showed increasing microbe inhibition with increasing drug concentrations. Bupivacaine at common epidural concentrations inhibited eight of the ten organisms and pethidine inhibited six. These findings confirm previous reports of microbe inhibition by bupivacaine, and in addition demonstrate a similar but slightly lesser activity by pethidine. Although antimicrobial activity of epidural drugs can be regarded as a desirable property, clinical implications of such findings remain unclear.
采用琼脂稀释法，研究了布比卡因和哌替啶在硬膜外麻醉常用浓度下对十种常见微生物的抗菌活性。两种药物均表现出随着药物浓度增加，抑菌作用增强。布比卡因在硬膜外常用浓度下对十种微生物中的八种有抑制作用，哌替啶对六种有抑制作用。这些发现证实了之前关于布比卡因抑菌作用的报道，此外还表明哌替啶有类似但稍弱的活性。虽然硬膜外用药的抗菌活性可被视为一种理想特性，但这些发现的临床意义仍不明确。
