细胞毒性药物的抗菌活性可能会影响从血培养物中分离细菌和真菌。
Antimicrobial activity of cytotoxic drugs may influence isolation of bacteria and fungi from blood cultures.
作者信息
Peiris V, Oppenheim B A
机构信息
Department of Microbiology, Withington Hospital, Manchester.
出版信息
J Clin Pathol. 1993 Dec;46(12):1124-5. doi: 10.1136/jcp.46.12.1124.
Abstract
The potential antimicrobial activity of cyclophosphamide, vincristine, and adriamycin against Gram positive and negative bacteria and Candida albicans was examined. The time taken for different microbial inocula to turn a simulated blood culture positive in the presence of different concentrations of these drugs was measured. Doxorubicin retarded the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus sanguis in a concentration dependent manner. Cyclophosphamide and vincristine showed minimal antimicrobial activity. Escherichia coli and Pseudomonas aeruginosa were unaffected by any of the drugs. An inoculum dependent effect was seen with some combinations of microbial inocula and cytotoxic drug concentrations.
摘要
研究了环磷酰胺、长春新碱和阿霉素对革兰氏阳性菌、革兰氏阴性菌及白色念珠菌的潜在抗菌活性。测定了在不同浓度的这些药物存在下，不同微生物接种物使模拟血培养呈阳性所需的时间。阿霉素以浓度依赖的方式抑制金黄色葡萄球菌、表皮葡萄球菌和血链球菌的生长。环磷酰胺和长春新碱显示出最小的抗菌活性。大肠杆菌和铜绿假单胞菌不受任何一种药物的影响。在一些微生物接种物和细胞毒性药物浓度的组合中观察到接种物依赖性效应。
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