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基于 MBSAQIP 数据库的减重手术后 30 天严重不良事件和再入院的新型风险预测模型。

A novel risk prediction model for 30-day severe adverse events and readmissions following bariatric surgery based on the MBSAQIP database.

机构信息

St Luke's University Hospital and Health Network, Lewis Katz School of Medicine at Temple University, Allentown, Pennsylvania.

St Luke's University Hospital and Health Network, Lewis Katz School of Medicine at Temple University, Allentown, Pennsylvania.

出版信息

Surg Obes Relat Dis. 2019 Jul;15(7):1138-1145. doi: 10.1016/j.soard.2019.03.005. Epub 2019 Mar 20.

DOI:10.1016/j.soard.2019.03.005
PMID:31053498
Abstract

BACKGROUND

Although bariatric surgery is safe, some patients fear serious complications.

OBJECTIVES

This retrospective study used the 2015 Metabolic and Bariatric Surgery Accreditation Quality Improvement Project (MBSAQIP) database to evaluate patient outcomes for gastric bypass (GB) and sleeve gastrectomy and to develop a risk prediction model for serious adverse events (SAEs) and readmission rates 30 days after surgery.

SETTING

MBSAQIP national patient database.

METHODS

We created separate exploratory multivariable logistic regression models for SAEs and readmissions. We then externally validated both models using the 2016 MBSAQIP Participant Use Data File.

RESULTS

Significant predictors of SAEs were preoperative body mass index (adjusted odds ratio [AOR] 1.07, P < .0001); GB surgery (AOR 2.08, P < .0001); cardiovascular disease (AOR 1.43, P < .0001); smoking (AOR 1.12, P = .04); diabetes (AOR 1.15, P = .0001); hypertension (AOR 1.17, P < .0001); limited ambulation (AOR 1.48, P < .0001); sleep apnea (AOR 1.12, P = .001); history of pulmonary embolism (AOR 2.81, P < .0001); and steroid use (AOR 1.40, P = .001). Significant predictors of readmissions were GB surgery (AOR 1.81, P < .0001); female sex (AOR 1.26, P < .0001); diabetes (AOR 1.08, P = .04); hypertension (AOR 1.11, P = .004); preoperative body mass index (AOR 1.05, P < .0001); sleep apnea (AOR 1.11, P = .002); history of pulmonary embolism (AOR 2.35, P < .0001); cardiovascular disease (AOR 1.61, P < .0001); smoking (AOR 1.14, P = .01); and limited ambulation (AOR 1.55, P < .0001). External validation supported these covariates, with similar model discriminative power.

CONCLUSIONS

Our exploratory regression models may be used by clinicians to counsel patients about surgical risks, although future external validation should occur in non-North American populations.

摘要

背景

减重手术是安全的,但一些患者仍担心会出现严重并发症。

目的

本回顾性研究使用 2015 年代谢和减重手术认证质量改进项目(MBSAQIP)数据库,评估胃旁路术(GB)和袖状胃切除术患者的术后结局,并建立术后 30 天严重不良事件(SAE)和再入院率的风险预测模型。

设置

MBSAQIP 全国患者数据库。

方法

我们分别为 SAE 和再入院创建了探索性多变量逻辑回归模型。然后,我们使用 2016 年 MBSAQIP 参与者使用数据文件对这两个模型进行了外部验证。

结果

SAE 的显著预测因素为术前体重指数(调整后优势比[OR]1.07,P<0.0001);GB 手术(OR 2.08,P<0.0001);心血管疾病(OR 1.43,P<0.0001);吸烟(OR 1.12,P=0.04);糖尿病(OR 1.15,P=0.0001);高血压(OR 1.17,P<0.0001);活动受限(OR 1.48,P<0.0001);睡眠呼吸暂停(OR 1.12,P=0.001);肺栓塞史(OR 2.81,P<0.0001);和使用类固醇(OR 1.40,P=0.001)。再入院的显著预测因素为 GB 手术(OR 1.81,P<0.0001);女性(OR 1.26,P<0.0001);糖尿病(OR 1.08,P=0.04);高血压(OR 1.11,P=0.004);术前体重指数(OR 1.05,P<0.0001);睡眠呼吸暂停(OR 1.11,P=0.002);肺栓塞史(OR 2.35,P<0.0001);心血管疾病(OR 1.61,P<0.0001);吸烟(OR 1.14,P=0.01);和活动受限(OR 1.55,P<0.0001)。外部验证支持这些协变量,模型具有相似的判别能力。

结论

我们的探索性回归模型可以帮助临床医生向患者提供手术风险方面的咨询,但未来应在非北美人群中进行外部验证。

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