Chronic Disease Research Institute, School of Public Health, and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China.
English Department, School of Humanities, Tsinghua University, Beijing, China.
Clin Nutr. 2020 Apr;39(4):1124-1130. doi: 10.1016/j.clnu.2019.04.023. Epub 2019 Apr 25.
It is unclear whether low muscle mass and low muscle strength are independently or jointly associated with nonalcoholic fatty liver disease (NAFLD). Hence, the aim of the present study was to investigate the associations of NAFLD with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.
A total of 5132 participants aged 18-80 years were recruited in this cross-sectional study. NAFLD was diagnosed using ultrasound. Muscle mass was evaluated using skeletal muscle mass index and muscle strength was evaluated using weight-adjusted hand grip strength. Sarcopenia was defined as the presence of both low muscle mass and low muscle strength. Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Multivariate logistic regression models were used to explore the associations of NAFLD with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.
Low muscle mass and low muscle strength were positively and independently associated with NAFLD (mass: odds ratio [OR], 2.57; 95% confidence interval [CI], 2.03-3.25; strength: OR, 1.47; 95% CI, 1.21-1.80). Compared with low muscle mass or low muscle strength alone, sarcopenia was associated with a higher risk of NAFLD (OR, 3.91; 95% CI, 2.90-5.28). Whether obesity was defined by body mass index (BMI) or waist circumference (WC), sarcopenic obesity was associated with a higher risk of NAFLD (BMI: OR, 10.42; 95% CI, 7.14-15.22; WC: OR, 11.64; 95% CI, 8.22-16.48) than sarcopenia or obesity alone.
Low muscle mass and low muscle strength were positively and independently associated with NAFLD. When both were presented in the sarcopenic state, the risk of NAFLD was higher, and a concurrence of sarcopenia and obesity showed the highest risk of NAFLD.
低肌肉量和低肌肉力量与非酒精性脂肪性肝病（NAFLD）之间的关系尚不清楚。因此，本研究旨在探讨 NAFLD 与低肌肉量、低肌肉力量、肌肉减少症和肌肉减少性肥胖的关系。
本横断面研究共纳入 5132 名 18-80 岁的参与者。使用超声诊断 NAFLD。肌肉量通过骨骼肌指数评估，肌肉力量通过体重校正的握力评估。肌肉减少症定义为同时存在低肌肉量和低肌肉力量。肌肉减少性肥胖定义为同时存在肌肉减少症和肥胖。使用多变量逻辑回归模型探讨 NAFLD 与低肌肉量、低肌肉力量、肌肉减少症和肌肉减少性肥胖的关系。
低肌肉量和低肌肉力量与 NAFLD 呈正相关且独立相关（肌肉量：比值比[OR]，2.57；95%置信区间[CI]，2.03-3.25；肌肉力量：OR，1.47；95%CI，1.21-1.80）。与单独的低肌肉量或低肌肉力量相比，肌肉减少症与更高的 NAFLD 风险相关（OR，3.91；95%CI，2.90-5.28）。无论肥胖是通过体重指数（BMI）还是腰围（WC）定义，肌肉减少性肥胖与更高的 NAFLD 风险相关（BMI：OR，10.42；95%CI，7.14-15.22；WC：OR，11.64；95%CI，8.22-16.48），而与肌肉减少症或肥胖单独相比。
低肌肉量和低肌肉力量与 NAFLD 呈正相关且独立相关。当两者同时存在于肌肉减少症状态时，NAFLD 的风险更高，并且肌肉减少症和肥胖的并存显示出最高的 NAFLD 风险。
