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南非创伤性脊髓损伤后急性住院时间的风险指标:一项前瞻性、基于人群的研究。

Risk indicators of length of acute hospital stay after traumatic spinal cord injury in South Africa: a prospective, population-based study.

机构信息

Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.

Karolinska University Hospital, Allied Health Professionals Function, Function Area Occupational Therapy & Physiotherapy, Stockholm, Sweden.

出版信息

Spinal Cord. 2019 Sep;57(9):763-769. doi: 10.1038/s41393-019-0286-0. Epub 2019 May 3.

Abstract

STUDY DESIGN

Population-based cohort study.

OBJECTIVES

To determine non-modifiable and modifiable risk indicators of acute length of hospital stay (LOHS) after traumatic spinal cord injury (TSCI).

SETTING

Government-funded hospitals within the City of Cape Town, South Africa.

METHODS

Newly injured survivors of TSCI during a 1 year period were prospectively included. Non-modifiable (e.g., demographic factors and clinical characteristics) and modifiable risk indicators (e.g., clinical processes, timing of surgery, secondary complications) of prolonged LOHS (31 days) were determined using univariate and multivariable logistic regression analyses.

RESULTS

Of the total population-based cohort of 145 individuals, 139 (96%) had valid LOHS data and were included in the analyses. Significant univariate non-modifiable risk indicators of LOHS were age, complete injury and vertebral injury, whereas modifiable risk indicators were delayed spinal surgery (>72 h) and the occurrence of any secondary complications, as well as specifically pressure ulcers, pneumonia and urinary tract infection. In the final multivariable model showing good fit and acceptable discrimination (AUC = 0.86), older age (OR: 1.04, 95% CI: 1.00-1.07), vertebral injury (OR: 3.18, 95% CI: 1.07-9.44), pneumonia (OR: 8.40, 95% CI: 2.76-25.55) and pressure ulcers (OR: 7.16, 95% CI: 2.54-20.22) remained significant independent factors. Only injury completeness was insignificant in the final model.

CONCLUSIONS

Our findings shed light on the need of developing prevention programs for secondary complications to improve the quality and efficiency of acute SCI care in South Africa.

SPONSORSHIP

The National Research Foundation of South Africa.

摘要

研究设计

基于人群的队列研究。

目的

确定外伤性脊髓损伤(TSCI)后急性住院时间(ALOS)延长的不可变和可改变的风险指标。

设置

南非开普敦市政府资助的医院。

方法

在 1 年期间,前瞻性纳入新发生的 TSCI 幸存者。使用单变量和多变量逻辑回归分析确定延长的 LOS(31 天)的不可变(例如,人口统计学因素和临床特征)和可改变的风险指标(例如,临床过程、手术时机、继发性并发症)。

结果

在基于人群的队列的 145 名个体中,有 139 名(96%)具有有效的 LOS 数据并被纳入分析。 LOS 的显著单变量不可变风险指标是年龄、完全性损伤和椎体损伤,而可改变的风险指标是脊柱手术延迟(>72 小时)和任何继发性并发症的发生,特别是压疮、肺炎和尿路感染。在最终的多变量模型中,拟合良好,区分度可接受(AUC=0.86),年龄较大(OR:1.04,95%CI:1.00-1.07)、椎体损伤(OR:3.18,95%CI:1.07-9.44)、肺炎(OR:8.40,95%CI:2.76-25.55)和压疮(OR:7.16,95%CI:2.54-20.22)仍然是显著的独立因素。只有损伤的完全性在最终模型中无统计学意义。

结论

我们的研究结果表明,需要制定继发性并发症的预防计划,以提高南非急性 SCI 护理的质量和效率。

赞助

南非国家研究基金会。

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