Rowley P T, Kosciolek B, Bader J L
Ann N Y Acad Sci. 1986;486:327-32. doi: 10.1111/j.1749-6632.1986.tb48085.x.
To investigate the role of oncogenes in malignancies characteristic of neurofibromatosis, oncogene transcripts were quantitated in a neurofibrosarcoma and in control tissue from a patient with hereditary neurofibromatosis. Sis and N-ras were moderately hyperexpressed, raf, Blym, and erbA were slightly hyperexpressed, and abl, erbB, fes/fps, fgr, fos, mos, myb, myc, N-myc, rasHarvey, rasKirsten, ros, src, and yes were not hyperexpressed in the tumor compared to the control tissue. Although additional tumors will be assayed before conclusions are possible, it may be significant that the two oncogenes most hyperexpressed are prior suspects for a pathogenetic role in tumors of the nervous system.
为研究癌基因在神经纤维瘤病特征性恶性肿瘤中的作用，对一名神经纤维肉瘤患者的肿瘤组织及遗传性神经纤维瘤病患者的对照组织中的癌基因转录本进行了定量分析。Sis和N-ras呈中度高表达，raf、Blym和erbA呈轻度高表达，与对照组织相比，abl、erbB、fes/fps、fgr、fos、mos、myb、myc、N-myc、rasHarvey、rasKirsten、ros、src和yes在肿瘤中未出现高表达。尽管在得出结论之前还将检测更多肿瘤，但两个高表达最明显的癌基因是神经系统肿瘤发病机制中先前被怀疑起作用的基因，这可能具有重要意义。
