玛格曼尼烷 A-H：从玉兰 var. 鹅掌楸树皮中分离得到的八种新的倍半萜类化合物。
Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Bioorg Chem. 2019 Jul;88:102948. doi: 10.1016/j.bioorg.2019.102948. Epub 2019 Apr 27.
Eight new meroterpenoids with different types of monoterpene units, namely, magmenthanes A-H (1-8), were identified from the bark of Magnolia officinalis var. biloba. Magmenthane A (1) possesses a 1,3-dioxabicyclo [4.3.0] nonane skeleton, 1-5 possess five pairs of enantiomers and 6 possesses a 1,1'-diallyl-biphenyl fragment. The structures of 1-8 were elucidated on the basis of 1D and 2D NMR, HRESIMS and electronic circular dichroism (ECD) calculations. Compounds 5 and 8 displayed significant PTP1B inhibitory activities with IC values of 4.38 and 3.88 μM, respectively.
从厚朴的树皮中分离得到了 8 个具有不同单萜单元类型的新倍半萜类化合物，分别命名为 magmenthanes A-H（1-8）。Magmenthane A（1）具有 1,3-二氧杂双环[4.3.0]壬烷骨架，1-5 具有五对对映异构体，6 具有 1,1'-二烯丙基联苯片段。基于 1D 和 2D NMR、HRESIMS 和电子圆二色性（ECD）计算，确定了 1-8 的结构。化合物 5 和 8 对 PTP1B 具有显著的抑制活性，IC 值分别为 4.38 和 3.88 μM。
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