Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Department of Traditional Medicine, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi, Viet Nam.
Bioorg Chem. 2020 Mar;96:103586. doi: 10.1016/j.bioorg.2020.103586. Epub 2020 Jan 16.
Six new obovatol trimeric neolignans, houpulignans A-F (1-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined on the basis of the interpretation of HRESIMS, NMR data, and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of neolignans derived from three units of obovatol bearing a rare 1,4-benzodioxepane moiety. Compound 3 possesses a benzodihydropyran ring, meanwhile three units of obovatol in 4-6 are connected by an alkyl chain. Compounds 1-3 inhibited NO production in LPS-stimulated RAW264.7 cells with IC values of 8.01, 20.21, and 4.05 µM, respectively.
从厚朴的叶子中分离得到了 6 个新的厚朴三萜类新木脂素，即厚朴素 A-F（1-6）。根据高分辨质谱（HRESIMS）、核磁共振（NMR）数据和电子圆二色性（ECD）计算结果，确定了它们的结构。化合物 1 和 2 是首例含有罕见的 1,4-苯并二氧杂环己烷部分的由三个厚朴素单元衍生而来的新木脂素。化合物 3 含有苯并二氢吡喃环，而 4-6 中的三个厚朴素单元通过烷基链连接。化合物 1-3 对 LPS 刺激的 RAW264.7 细胞中 NO 的产生具有抑制作用，IC50 值分别为 8.01、20.21 和 4.05 µM。
