State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College . Beijing 100050 , People's Republic of China.
Org Lett. 2018 Jun 15;20(12):3682-3686. doi: 10.1021/acs.orglett.8b01476. Epub 2018 Jun 4.
Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo[5.3.1.0]undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6-C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways of 1-3 are presented. Compounds 1 and 3 exhibited significant PTP1B inhibitory activities with IC values of 1.44 and 0.81 μM, respectively.
马兜铃烷型倍半萜 A（1），具有罕见的 4,6,11-三氧杂三环[5.3.1.0]十一烷骨架和不规则的单萜部分；马兜铃烷型倍半萜 B（2），具有前所未有的 6/6/6/6 多环骨架；倍半萜醌 C（3），是一种具有 C6-C3 单元的新型萜类醌。提出了 1-3 的可能生物合成途径。化合物 1 和 3 对 PTP1B 具有显著的抑制活性，IC50 值分别为 1.44 和 0.81 μM。
