Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, PR China; State Key Laboratory of Long-Acting and Targeting Drug Delivery System, Shandong Luye Pharmaceutical Co., Ltd, Yantai 264003, PR China.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Department of Chemical Engineering and Material Science, Wayne State University, Detroit, MI 48202, USA.
Colloids Surf B Biointerfaces. 2019 Aug 1;180:202-211. doi: 10.1016/j.colsurfb.2019.04.050. Epub 2019 Apr 25.
Drug self-delivery systems exactly present nanoscale characteristics without the support of any external carrier materials, have been rapidly developed because of low-cost preparation, excellent and fixed drug loading capacity, no need for carrier synthesis and no carrier-induced toxicity and immunogenicity. In general, amphipathy is indispensable for such design, for the amphiphilic drug conjugates could spontaneously self-assemble into nano-sized architectures above a critical concentration. Nevertheless, some elaborate designs on bonds and specified conjugates with no amphipathy anymore appeared in recent years, which create a novel and broad platform for the fabrication of hydrophobic drug self-delivery systems (HDSDSs), involving lipid-drug conjugates, drug-drug conjugates, and fluorescent dye -drug conjugates. In this review, we present the major types of HDSDSs and expound their self-assembly mechanism and fabrication strategies. And we emphatically discuss some representative achievements of these different types of HDSDSs for monotherapy, combinational therapy and theranostics in the aspect of cancer therapy. In addition, we discuss the future prospects of such kind of nanomedicine, which hold a span-new direction for cancer therapy on account of the excellent drug behavior in vitro and in vivo and the great potential to standardize the commercial production.
药物自传递系统无需任何外部载体材料的支持即可呈现出纳米级特征，由于其低成本的制备、出色且固定的载药量、无需载体合成以及载体引起的毒性和免疫原性等优点，因此得到了快速发展。一般来说，这种设计离不开两亲性，因为两亲性药物缀合物在临界浓度以上会自发自组装成纳米尺寸的结构。然而，近年来出现了一些在键和特定缀合物上的精心设计，这些设计不再需要两亲性，为疏水性药物自传递系统（HDSDS）的制备创造了一个新颖而广阔的平台，涉及脂质-药物缀合物、药物-药物缀合物和荧光染料-药物缀合物。在这篇综述中，我们介绍了 HDSDS 的主要类型，并阐述了它们的自组装机制和制备策略。我们还着重讨论了这些不同类型的 HDSDS 在癌症治疗方面的单药治疗、联合治疗和治疗学方面的一些代表性成就。此外，我们还讨论了这种纳米医学的未来前景，由于其在体外和体内具有优异的药物行为以及使商业化生产标准化的巨大潜力，为癌症治疗开辟了全新的方向。
