Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Pathol Res Pract. 2019 Jun;215(6):152426. doi: 10.1016/j.prp.2019.04.018. Epub 2019 Apr 28.
Several studies have indicated that lncRNA loc285194 is aberrantly expressed in many types of cancer. This meta-analysis was performed to elucidate the potential role of lncRNA loc285194 as a prognostic marker in malignant tumors.
An electronic search of PubMed, Medline, Embase, and Web of Science was performed to identify all eligible papers related to the prognostic impact of lncRNA loc285194 expression in cancer. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted from the included studies to explore the association between lncRNA loc285194 expression and patient overall and disease-free survival (OS & DFS). The odds ratios (ORs) were also calculated to assess the association between lncRNA loc285194 expression and clinicopathological parameters.
A total of 14 eligible articles with 1215 patients were included in this meta-analysis. Meta-results revealed that low expression of lncRNA loc285194 was significantly correlated with poorer overall survival (OS; HR = 2.34; 95% CI, 1.78-3.06; P < 0.001) and disease-free survival (DFS; HR = 2.66; 95% CI, 1.95-3.64; P = 0.001) rates in cancer patients. Low lncRNA loc285194 expression was also found to be significantly associated with lymph node metastasis (LNM; OR = 2.17; 95% CI, 1.23-3.83; P = 0.007), and distant metastasis (DM; OR = 2.49; 95% CI, 1.26-4.91; P = 0.009).
This study demonstrated that decreased level of lncRNA loc285194 was associated with poor clinical outcomes for patients with different types of cancer, supporting a promising potential biomarker for prognosis and metastasis in human cancers.
多项研究表明，lncRNA loc285194 在多种类型的癌症中表达异常。本荟萃分析旨在阐明 lncRNA loc285194 作为恶性肿瘤预后标志物的潜在作用。
通过电子检索 PubMed、Medline、Embase 和 Web of Science，以确定与癌症中 lncRNA loc285194 表达的预后影响相关的所有合格文献。从纳入的研究中提取风险比（HR）和 95%置信区间（CI），以探讨 lncRNA loc285194 表达与患者总生存期（OS）和无病生存期（DFS）之间的关系。还计算了比值比（OR）以评估 lncRNA loc285194 表达与临床病理参数之间的关系。
本荟萃分析共纳入 14 项符合条件的研究，包含 1215 名患者。荟萃分析结果表明，lncRNA loc285194 低表达与癌症患者总体生存率（OS；HR=2.34；95%CI，1.78-3.06；P<0.001）和无病生存率（DFS；HR=2.66；95%CI，1.95-3.64；P=0.001）下降显著相关。lncRNA loc285194 低表达也与淋巴结转移（LNM；OR=2.17；95%CI，1.23-3.83；P=0.007）和远处转移（DM；OR=2.49；95%CI，1.26-4.91；P=0.009）显著相关。
本研究表明，lncRNA loc285194 水平降低与不同类型癌症患者的临床结局不良相关，支持其作为人类癌症预后和转移的有前途的潜在生物标志物。
