在中国贻贝（Mytilus coruscus）套膜中鉴定出的两种 Toll 样受体在血细胞中大量存在。
Two toll-like receptors identified in the mantle of Mytilus coruscus are abundant in haemocytes.
机构信息
International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China.
International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.
出版信息
Fish Shellfish Immunol. 2019 Jul;90:134-140. doi: 10.1016/j.fsi.2019.05.001. Epub 2019 May 2.
Toll-like receptors (TLRs) are a large family of pattern recognition receptors (PRRs) that play a critical role in innate immunity. TLRs are activated when they recognize microbial associated molecular patterns (MAMPs) of bacteria, viruses, or fungus. In the present study, two TLRs were isolated from the mantle of the hard-shelled mussel (Mytilus coruscus) and designated McTLR2 and McTLR3 based on their sequence similarity and phylogenetic clustering with Crassostrea gigas, CgiTLR2 and CgiTLR3, respectively. Quantitative RT-PCR analysis demonstrated that McTLR2 and McTLR3 were constitutively expressed in many tissues but at low abundance.
Toll 样受体（TLRs）是一类重要的模式识别受体（PRRs），在先天免疫中发挥关键作用。TLRs 识别细菌、病毒或真菌的微生物相关分子模式（MAMPs）后被激活。在本研究中，从硬壳贻贝（Mytilus coruscus）的套膜中分离到两个 TLR，并根据其与皱纹盘鲍（Crassostrea gigas）的序列相似性和系统发育聚类，分别命名为 McTLR2 和 McTLR3。定量 RT-PCR 分析表明，McTLR2 和 McTLR3 在多种组织中持续表达，但丰度较低。
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