Department of Neurobiology School of Basic Medical Sciences, Center of Parkinson Disease Beijing Institute for Brain Disorders, Beijing Key Laboratory for Neural Regeneration and Repair, Beijing Key Laboratory on Parkinson's Disease, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Capital Medical University, Beijing, 100069, China.
Department of Neurobiology School of Basic Medical Sciences, Center of Parkinson Disease Beijing Institute for Brain Disorders, Beijing Key Laboratory for Neural Regeneration and Repair, Beijing Key Laboratory on Parkinson's Disease, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Capital Medical University, Beijing, 100069, China.
Biomed Pharmacother. 2019 Jul;115:108843. doi: 10.1016/j.biopha.2019.108843. Epub 2019 May 2.
Many neurodegenerative diseases are characterized by progressive loss of neurons and abnormal protein accumulation, including amyloid (A)β and tau in Alzheimer's disease and Lewy bodies and α-synuclein (α-syn) in Parkinson's disease (PD). Recent evidence suggests that adaptive immunity plays an important role in PD, and that anti-α-syn antibodies can be used as therapy in neurodegenerative diseases; monoclonal antibodies were shown to inhibit α-syn propagation and aggregation in PD models and patients. In this review, we summarize the different pathological states of α-syn, including gene mutations, truncation, phosphorylation, and the high molecular weight form, and describe the specific antibodies that recognize the α-syn monomer or oligomer, some of which have been tested in clinic trials. We also discuss future research directions and potential targets in PD therapy.
许多神经退行性疾病的特征是神经元进行性丧失和异常蛋白质积累，包括阿尔茨海默病中的淀粉样蛋白 (A)β 和 tau，以及帕金森病中的路易体和 α-突触核蛋白 (α-syn)。最近的证据表明，适应性免疫在帕金森病中起着重要作用，并且抗 α-syn 抗体可用作神经退行性疾病的治疗方法；单克隆抗体已被证明可抑制帕金森病模型和患者中 α-syn 的传播和聚集。在这篇综述中，我们总结了 α-syn 的不同病理状态，包括基因突变、截断、磷酸化和高分子量形式，并描述了识别 α-syn 单体或寡聚体的特异性抗体，其中一些已在临床试验中进行了测试。我们还讨论了帕金森病治疗的未来研究方向和潜在靶点。
