Vintzileos A M, Campbell W A, Deaton J L, Nochimson D J, Weinbaum P J
Am J Perinatol. 1987 Apr;4(2):115-20. doi: 10.1055/s-2007-999751.
Described is a pregnancy complicated by severe Rh sensitization and hydrops fetalis which was managed aggressively with frequent intrauterine transfusions initiated at 21 1/2 weeks of gestation. No improvement or only temporary improvement of the fetal hydrops was observed after each intrauterine transfusion. Postmortem examination of the infant revealed the additional presence of nonimmunologic factors involved such as pulmonic atresia and lung hypoplasia. In cases of severe Rh sensitization associated with persistent fetal hydrops despite frequent intrauterine transfusions, the presence of coexistent factors for nonimmunologic fetal hydrops should be considered.
描述了一例妊娠合并严重Rh致敏和胎儿水肿的病例，该病例在妊娠21.5周时开始频繁进行宫内输血，积极进行处理。每次宫内输血后，未观察到胎儿水肿有改善或仅暂时改善。婴儿的尸检显示还存在其他相关的非免疫因素，如肺动脉闭锁和肺发育不全。在严重Rh致敏且尽管频繁进行宫内输血仍持续存在胎儿水肿的病例中，应考虑存在非免疫性胎儿水肿的共存因素。
