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三维虚拟模型和打印模型改善复杂先天性和小儿心脏手术的术前规划并提高患者安全性

[Three-dimensional virtual and printed models improve preoperative planning and promote patient-safety in complex congenital and pediatric cardiac surgery].

作者信息

Király László

机构信息

Pediatric Cardiac Surgery, Cardiac Sciences, Sheikh Khalifa Medical City Al Karamah Street, POB 51900, Abu Dhabi, United Arab Emirates.

Népegészségtani Intézet, Semmelweis Egyetem Budapest.

出版信息

Orv Hetil. 2019 May;160(19):747-755. doi: 10.1556/650.2019.31393.

Abstract

Three-dimensional (3D) modelling and printing greatly supports advances in individualized medicine and surgery. In congenital cardiac surgery, 3D-models and printed prototypes offer advantages of better understanding of complex anatomy, hands-on preoperative surgical planning and emulation, improved communication within the multidisciplinary team and to patients. 3D-virtual and printed models often add important new anatomical findings and prompt alternative operative scenarios. Validity and realisation of possible clinical benefits were studied. Computed tomography-angiography raw-data were segmented into 3D-virtual models of the heart-great vessels. Prototypes were 3D-printed as real-size "blood-volume" (rigid material), and 1.5×-scaled "hollow" (translucent, flexible material). Accuracy of the models was evaluated intraoperatively. We produced 3D-prototypes of the heart-great vessels for 12 case-scenarios (6 males, median age: 11 months) undergoing complex intracardiac repairs. Accuracy was excellent in millimeter-range. Representation of the atrioventricular valves is currently unsatisfactory. Models refined diagnostics in 8/12 and provided new anatomic information in 6/12 cases (e.g., aberrant coronary origin/course, newly-discovered intracardiac communication, etc.); in 10/12 cases they contributed to an improved operative plan (surgical approach, modification of intracardiac repair, etc.); an alternative operative plan emerged in 6/12 cases. Complex operative procedures (staged reoperations in 10/12; Aristotle-score median: 11; 10-14) emulated on 3D-models were materialized successfully. No morbidity/mortality occurred. Acceptance-index of the 3D-models was maximal among the multidisciplinary clinical team and patients/relatives. 3D-printed models can contribute to the safety of complex congenital cardiac surgeries in selected scenarios. Besides their numerous benefits, currently inadequate financial coverage of the extra time/labour and material/machinery by insurance is mentioned as a major drawback. Orv Hetil. 2019; 160(19): 747-755.

摘要

三维(3D)建模与打印极大地推动了个性化医学与手术的发展。在先天性心脏手术中,3D模型和打印原型具有诸多优势,有助于更好地理解复杂解剖结构、进行术前实际手术规划与模拟、改善多学科团队内部以及与患者之间的沟通。3D虚拟模型和打印模型常常能带来重要的新解剖学发现,并促使产生其他手术方案。研究了可能的临床益处的有效性及实现情况。将计算机断层扫描血管造影原始数据分割成心脏大血管的3D虚拟模型。原型采用3D打印,制成真实尺寸的“血容量”模型(刚性材料)和1.5倍比例的“中空”模型(半透明、柔性材料)。术中评估模型的准确性。我们为12例(6例男性,中位年龄:11个月)接受复杂心内修复手术的病例制作了心脏大血管的3D原型。毫米级的准确性极佳。房室瓣的呈现目前并不理想。模型在8/12的病例中完善了诊断,并在6/12的病例中提供了新的解剖学信息(如冠状动脉起源/走行异常、新发现的心内交通等);在10/12的病例中,它们有助于改进手术方案(手术入路、心内修复的修改等);在6/12的病例中出现了替代手术方案。在3D模型上模拟的复杂手术操作(10/12为分期再次手术;亚里士多德评分中位值:11;10 - 14)成功得以实施。未发生 morbidity/mortality。3D模型在多学科临床团队以及患者/亲属中的接受指数最高。3D打印模型在特定情况下有助于复杂先天性心脏手术的安全性。除了众多益处外,目前保险对额外时间/人力以及材料/机器的资金覆盖不足被提及为一个主要缺点。《匈牙利医学周报》。2019年;160(19): 747 - 755。 (注:“morbidity/mortality”在医学领域有特定含义,此处直接保留英文,因为准确翻译需结合具体语境确定更合适的中文表述,如“发病率/死亡率”等,但原文未明确其准确指向,所以保留英文更严谨。)

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