Király László
Pediatric Cardiac Surgery, Cardiac Sciences, Sheikh Khalifa Medical City Al Karamah Street, POB 51900, Abu Dhabi, United Arab Emirates.
Népegészségtani Intézet, Semmelweis Egyetem Budapest.
Orv Hetil. 2019 May;160(19):747-755. doi: 10.1556/650.2019.31393.
Three-dimensional (3D) modelling and printing greatly supports advances in individualized medicine and surgery. In congenital cardiac surgery, 3D-models and printed prototypes offer advantages of better understanding of complex anatomy, hands-on preoperative surgical planning and emulation, improved communication within the multidisciplinary team and to patients. 3D-virtual and printed models often add important new anatomical findings and prompt alternative operative scenarios. Validity and realisation of possible clinical benefits were studied. Computed tomography-angiography raw-data were segmented into 3D-virtual models of the heart-great vessels. Prototypes were 3D-printed as real-size "blood-volume" (rigid material), and 1.5×-scaled "hollow" (translucent, flexible material). Accuracy of the models was evaluated intraoperatively. We produced 3D-prototypes of the heart-great vessels for 12 case-scenarios (6 males, median age: 11 months) undergoing complex intracardiac repairs. Accuracy was excellent in millimeter-range. Representation of the atrioventricular valves is currently unsatisfactory. Models refined diagnostics in 8/12 and provided new anatomic information in 6/12 cases (e.g., aberrant coronary origin/course, newly-discovered intracardiac communication, etc.); in 10/12 cases they contributed to an improved operative plan (surgical approach, modification of intracardiac repair, etc.); an alternative operative plan emerged in 6/12 cases. Complex operative procedures (staged reoperations in 10/12; Aristotle-score median: 11; 10-14) emulated on 3D-models were materialized successfully. No morbidity/mortality occurred. Acceptance-index of the 3D-models was maximal among the multidisciplinary clinical team and patients/relatives. 3D-printed models can contribute to the safety of complex congenital cardiac surgeries in selected scenarios. Besides their numerous benefits, currently inadequate financial coverage of the extra time/labour and material/machinery by insurance is mentioned as a major drawback. Orv Hetil. 2019; 160(19): 747-755.
三维(3D)建模与打印极大地推动了个性化医学与手术的发展。在先天性心脏手术中,3D模型和打印原型具有诸多优势,有助于更好地理解复杂解剖结构、进行术前实际手术规划与模拟、改善多学科团队内部以及与患者之间的沟通。3D虚拟模型和打印模型常常能带来重要的新解剖学发现,并促使产生其他手术方案。研究了可能的临床益处的有效性及实现情况。将计算机断层扫描血管造影原始数据分割成心脏大血管的3D虚拟模型。原型采用3D打印,制成真实尺寸的“血容量”模型(刚性材料)和1.5倍比例的“中空”模型(半透明、柔性材料)。术中评估模型的准确性。我们为12例(6例男性,中位年龄:11个月)接受复杂心内修复手术的病例制作了心脏大血管的3D原型。毫米级的准确性极佳。房室瓣的呈现目前并不理想。模型在8/12的病例中完善了诊断,并在6/12的病例中提供了新的解剖学信息(如冠状动脉起源/走行异常、新发现的心内交通等);在10/12的病例中,它们有助于改进手术方案(手术入路、心内修复的修改等);在6/12的病例中出现了替代手术方案。在3D模型上模拟的复杂手术操作(10/12为分期再次手术;亚里士多德评分中位值:11;10 - 14)成功得以实施。未发生 morbidity/mortality。3D模型在多学科临床团队以及患者/亲属中的接受指数最高。3D打印模型在特定情况下有助于复杂先天性心脏手术的安全性。除了众多益处外,目前保险对额外时间/人力以及材料/机器的资金覆盖不足被提及为一个主要缺点。《匈牙利医学周报》。2019年;160(19): 747 - 755。 (注:“morbidity/mortality”在医学领域有特定含义,此处直接保留英文,因为准确翻译需结合具体语境确定更合适的中文表述,如“发病率/死亡率”等,但原文未明确其准确指向,所以保留英文更严谨。)