宿主遗传学、饮食和微生物组：AMY1 的作用。

Host Genetics, Diet, and Microbiome: The Role of AMY1.

机构信息

Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City 03940, Mexico; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.

Laboratorio de Enfermedades Cardiovasculares, INMEGEN, Mexico City 14610, Mexico.

出版信息

Trends Microbiol. 2019 Jun;27(6):473-475. doi: 10.1016/j.tim.2019.04.001. Epub 2019 May 2.

DOI:10.1016/j.tim.2019.04.001

PMID:31056302

Abstract

Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. (Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function. Complex genetics-diet-microbiome interactions and their effect on obesity could eventually translate into personalized nutrition.

摘要

由饮食适应选择的宿主基因变异与微生物组有关。Poole 等人（Cell Host Microbe 2019；25；553-564.E7）报道称，与肥胖相关的 AMY1 拷贝数也会影响微生物组的组成和功能。复杂的遗传-饮食-微生物组相互作用及其对肥胖的影响最终可能转化为个性化营养。