Godar Manita Sunam, Sharma Ananda Kumar, Thapa Madhu, Sitaula Sanjeeta, Gamal Nita Sunam, Manandhar Laxmi Devi
Lumbini Eye Institute, Shree Rana Ambika Shah Eye Hospital, Bhairahawa, Rupandehi.
Nepal J Ophthalmol. 2018 Jul;10(20):156-161. doi: 10.3126/nepjoph.v10i2.23025.
Optic neuritis (ON) is the involvement of the optic nerve as a result of inflammation, demyelination or infection.
To study the correlation between peripapillary retinal nerve fibre layer thickness (pRNFL) and visual evoked potential (VEP) in ON cases.
A non-interventional, descriptive, cross sectional study enrolling 66 eyes of 49 patients with ON was done. pRNFL thickness was measured by Optical Coherence Tomography (OCT) and VEP was also done. OCT and VEP findings were compared with the control group. In addition correlation between pRNFL thickness and VEP was done.
The mean pRNFL in affected eyes were significantly higher than the control superiorly (p-value<0.001), inferiorly (p-value <0.001), temporally (p-value 0.005) and nasally (p-value <0.001). The mean P100 latency in the affected eyes were significantly prolonged than the control eyes both at 1º (p-value<0.001) and at 15' (p-value=0.05). The mean N75-P100 amplitude in the affected eyes were significantly reduced than the control eyes both at 1º (p-value<0.001) and at 15' (p-value<0.001). The mean pRNFL thickness in all four quadrants and VEP findings of the affected eyes showed no significant correlation.
The increased thickness in non-myelinated pRNFL has no correlation with the increased latency or decreased amplitude in cases of ON. However, OCT is seen as a useful tool in detecting and quantifying even subtle pRNFL changes in cases of optic neuritis.
视神经炎（ON）是由炎症、脱髓鞘或感染导致的视神经受累。
研究视神经炎患者视乳头周围视网膜神经纤维层厚度（pRNFL）与视觉诱发电位（VEP）之间的相关性。
进行了一项非干预性、描述性横断面研究，纳入了49例视神经炎患者的66只眼。通过光学相干断层扫描（OCT）测量pRNFL厚度，并进行VEP检查。将OCT和VEP的结果与对照组进行比较。此外，还分析了pRNFL厚度与VEP之间的相关性。
患眼的平均pRNFL厚度在上方（p值<0.001）、下方（p值<0.001）、颞侧（p值0.005）和鼻侧（p值<0.001）均显著高于对照组。患眼的平均P100潜伏期在1°（p值<0.001）和15'（p值=0.05）时均显著长于对照眼。患眼的平均N75-P100波幅在1°（p值<0.001）和15'（p值<0.001）时均显著低于对照眼。患眼所有四个象限的平均pRNFL厚度与VEP结果之间无显著相关性。
在视神经炎病例中，无髓鞘pRNFL厚度增加与潜伏期延长或波幅降低无关。然而，OCT被视为检测和量化视神经炎病例中即使是细微的pRNFL变化的有用工具。
