School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.
Seattle Children's Hospital, Washington.
J Infect Dis. 2019 Aug 9;220(6):956-960. doi: 10.1093/infdis/jiz212.
In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.
在这项尼泊尔社区为基础、随机产前流感疫苗接种试验的事后分析中，对每周进行婴儿呼吸道疾病监测，457 名患有流感、呼吸道合胞病毒（RSV）或人偏肺病毒（hMPV）疾病的 605 名婴儿中有 457 名（75.5%）检测到肺炎球菌。肺炎球菌携带并未影响这 3 种病毒的下呼吸道疾病发生率。与母亲接受安慰剂的流感阳性婴儿相比，接种流感疫苗的母亲所生的流感阳性婴儿的肺炎球菌携带率较低（58.1%比 71.6%，P=0.03）。母亲流感免疫可能会影响婴儿在流感感染期间获得肺炎球菌。临床试验注册。NCT01034254。
