Bauer Robert J
Pharmacometrics, R&D, ICON Clinical Research LLC, Gaithersburg, MD20878.
CPT Pharmacometrics Syst Pharmacol. 2019 Aug;8(8):525-537. doi: 10.1002/psp4.12404. Epub 2019 Jun 13.
In this tutorial, the various components of NONMEM will be described, and the basic steps of setting up NONMEM control stream files and data files will be demonstrated. Some basic concepts of nonlinear mixed effects modeling will be discussed, along with simple examples demonstrating how to use NONMEM to perform population analysis of clinical data.
在本教程中,将描述NONMEM的各个组件,并演示设置NONMEM控制流文件和数据文件的基本步骤。将讨论非线性混合效应建模的一些基本概念,并给出简单示例,说明如何使用NONMEM对临床数据进行群体分析。