来自……的中国沉香中具有抗氧化性的2-(2-苯乙基)色酮
Antioxidative 2-(2-phenylethyl)chromones in Chinese eaglewood from .
作者信息
Li Chun-Ge, Pan Li, Han Zhu-Zhen, Xie Yan-Qiao, Hu Hai-Jun, Liu Xiao-Long, Wu Li-Hong, Yang Li, Wang Zheng-Tao
机构信息
The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201210, China.
出版信息
J Asian Nat Prod Res. 2020 Jul;22(7):639-646. doi: 10.1080/10286020.2019.1607841. Epub 2019 May 5.
Two new compounds 6,7-dimethoxy-2-[2-(2'-hydroxyphenyl)ethyl]chromone () and 6,7-dimethoxy-2-[2-(4'-hydroxyphenyl)ethenyl]chromone (), together with ten known 2-(2-phenylethyl)chromones (-) were isolated from the resinous wood of (Lour.) Gilg. Their structures were elucidated by detailed IR, MS, NMR spectroscopic analyses, and comparison with reported. The absolute configuration of was confirmed by Cu Kα X-ray crystallographic experiment, and the X-ray crystallographic data of were firstly reported. Compounds , , , and exhibited strong ABTS radical scavenging activity, with IC values of 12.3, 16.5, 12.1, and 34.7 μM, respectively.[Formula: see text].
从（Lour.）Gilg的树脂木材中分离出两种新化合物6,7-二甲氧基-2-[2-(2'-羟基苯基)乙基]色酮（）和6,7-二甲氧基-2-[2-(4'-羟基苯基)乙烯基]色酮（），以及十种已知的2-(2-苯乙基)色酮（-）。通过详细的红外光谱、质谱、核磁共振光谱分析并与报道的结果进行比较，阐明了它们的结构。通过铜Kα X射线晶体学实验确定了的绝对构型，并首次报道了的X射线晶体学数据。化合物、、、和表现出较强的ABTS自由基清除活性，IC值分别为12.3、16.5、12.1和34.7μM。[分子式：见正文]
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