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三新二聚体 2-(2-苯乙基)色酮从人工沉香的.

Three new dimeric 2-(2-phenylethyl)chromones from artificial agarwood of .

机构信息

Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.

出版信息

Nat Prod Res. 2021 Nov;35(21):3592-3598. doi: 10.1080/14786419.2020.1716345. Epub 2020 Jan 25.

Abstract

Three new dimeric 2-(2-phenylethyl)chromones crassin I ∼ K (-), together with one known analogue (), were isolated from the artificial holing agarwood originating from . Their structures including the absolute configuration were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR, ECD), and HRESIMS analysis, as well as by comparison with the literature data. Compounds and exhibited weak acetylcholinesterase inhibitory activity.

摘要

三种新的二聚体 2-(2-苯乙基)色酮 crassin I∼K(-),以及一种已知的类似物(),从人工打孔沉香中分离得到。通过光谱技术(UV、IR、1D 和 2D NMR、ECD)、高分辨率质谱分析以及与文献数据的比较,阐明了它们的结构,包括绝对构型。化合物和表现出微弱的乙酰胆碱酯酶抑制活性。

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