Wu Andrew C K, Van Werven Folkert J
a Cell Fate and Gene Regulation Laboratory , The Francis Crick Institute , London , UK.
Transcription. 2019 Jun;10(3):164-170. doi: 10.1080/21541264.2019.1608716. Epub 2019 May 5.
In eukaryotes, divergent transcription is a major source of noncoding RNAs. Recent studies have uncovered that in yeast, the transcription factor Rap1 restricts transcription in the divergent direction and thereby controls promoter directionality. Here, we summarize these findings, propose regulatory principles, and discuss the implications for eukaryotic gene regulation.
在真核生物中，双向转录是非编码RNA的主要来源。最近的研究发现，在酵母中，转录因子Rap1会限制双向转录，从而控制启动子的方向性。在此，我们总结这些发现，提出调控原则，并讨论其对真核生物基因调控的意义。
