男性不育症的代谢组学：诊断测试的新工具。
Metabolomics of Male Infertility: A New Tool for Diagnostic Tests.
作者信息
Mehrparavar Bahareh, Minai-Tehrani Arash, Arjmand Babak, Gilany Kambiz
机构信息
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
出版信息
J Reprod Infertil. 2019 Apr-Jun;20(2):64-69.
Abstract
Infertility is a major health issue worldwide. Males and females contribute equally to this problem. Diagnostic semen analysis fails to identify 50% of male infertility disorders. In this regard, metabolomics as a new field of omics has been suggested to have the potential of solving and diagnosis of the male infertility problems. Metabo-lome has a history of around 20 years. However, there are only limited metabolomics studies carried out regarding male infertility. In this review, the current metabolomics researches that have been done in infertile men were reviewed. Based on our own results, using human seminal plasma for metabolomics studies is highly recommended to find potential biomarkers and developing diagnosis tests for detection of main deficiencies in infertile men.
摘要
不孕不育是全球范围内的一个重大健康问题。男性和女性对此问题的影响程度相同。诊断性精液分析无法识别50%的男性不育症。在这方面，代谢组学作为组学的一个新领域，被认为有解决和诊断男性不育问题的潜力。代谢组学已有约20年的历史。然而，关于男性不育的代谢组学研究仍然有限。在本综述中，对目前在不育男性中进行的代谢组学研究进行了综述。基于我们自己的研究结果，强烈建议使用人类精浆进行代谢组学研究，以寻找潜在的生物标志物，并开发诊断测试以检测不育男性的主要缺陷。
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