Watanabe Hiroyuki, Sano Hajime, Maki Atsuko, Ino Takeshi, Nakagawa Takahito, Okamoto Makito, Yamashita Taku
Department of Otolaryngology, Head and Neck Surgery, Kitasato University, School of Medicine, Sagamihara, Japan.
Kitasato University, School of Allied Health Sciences, Sagamihara, Japan.
J Int Adv Otol. 2019 Apr;15(1):51-55. doi: 10.5152/iao.2019.6197.
We hypothesized that patients with idiopathic sudden sensorineural hearing loss (ISSHL) would have experienced more stress prior to the onset than they typically did. This study investigated stress levels in patients before the onset of ISSHL.
Forty-two patients with ISSHL were investigated. We used an original questionnaire to evaluate subjective stress levels in 1 week before onset. Serum hemoglobin A1c (HbA1c) and total cholesterol were examined to evaluate biochemical stress markers reflecting the preceding 1 to 2 months. The results on admission were compared with those at the follow-up visit.
Significantly more patients reported greater physical exhaustion, greater mental exhaustion, or a worse physical condition on admission than at follow-up (p<0.01, for each variable). On admission, 81% of patients reported greater than normal stress with regard to at least 1 of 3 items. The mean serum HbA1c was slightly but nonsignificantly lower at the follow-up visit (p=0.10), while the mean serum total cholesterol was significantly lower at follow-up than on admission (p<0.01).
The results indicate that patients were under a greater degree of stress before the onset of ISSHL, suggesting that stress plays a role in inducing ISSHL.
我们假设特发性突发性感音神经性听力损失（ISSHL）患者在发病前经历的压力比其平时更大。本研究调查了ISSHL患者发病前的压力水平。
对42例ISSHL患者进行了调查。我们使用一份原创问卷来评估发病前1周的主观压力水平。检测血清糖化血红蛋白（HbA1c）和总胆固醇，以评估反映前1至2个月情况的生化压力标志物。将入院时的结果与随访时的结果进行比较。
与随访时相比，显著更多的患者在入院时报告有更大程度的身体疲惫、精神疲惫或身体状况更差（每个变量p<0.01）。入院时，81%的患者报告在3项中的至少1项上压力大于正常水平。随访时血清HbA1c均值略低，但无显著差异（p=0.10），而随访时血清总胆固醇均值显著低于入院时（p<0.01）。
结果表明，ISSHL患者在发病前处于更大程度的压力之下，提示压力在诱发ISSHL中起作用。
